DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and C50D2.2

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_493662.1	Gene:	C50D2.2 / 183650	WormBaseID:	WBGene00016806	Length:	589	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	232/576 - (40%)
Similarity:	338/576 - (58%)	Gaps:	67/576 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAEFGARVP 100
            |.:.||.||:|.||:|..:|.|:|||.|.|.:..|||::::|||:|..||:.:.|||||||||.|
Worm    25 LRRCLSTFDITLLGVGHMIGAGIYVLTGSVVRNTAGPSIILSFLLAGFASLLSALCYAEFGARFP 89

  Fly   101 KAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQLCGNPMSSFLGT-----HM 160
            ||||||.|:||.:||..||:||||:|||:.:|:|:|.:..|.|||.|.||.:|:  .|     |:
Worm    90 KAGSAYTYTYVGVGELWAFVIGWNIILEHMLGAAAVARSWSGYLDSLLGNVISN--STIARTGHL 152

  Fly   161 PLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSSNWS 225
            .......|.||||.||::.:|.:..:|:|:|.||..|:..|:||:|:|:.|:..|:.....|.|
Worm   153 HEASSFFGDYPDLLAFLLIVLVAFFVALGSKVSTNFNSFLTILNIGIVVIVVFYGITFADFSLW- 216

  Fly   226 IPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMI 290
               |.|.| .|:..|.||||||:..|||.||:.:||||.:||||||||:|.:|||.|...|:.::
Worm   217 ---SGVDE-KGNSRFFPYGVSGMFAGAASCFFAYIGFDGLATAGEEAKDPARSIPIATFSSMTIV 277

  Fly   291 FLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIV 355
            .|:|..:|..||:|:||......|.....|.:.|...|.|.||:||:||:.:|::|.||.|||.|
Worm   278 TLSYVLMSASLTLMIPYNMVHPTAAFSDAFTMRGAEFASYAVSVGALFGMTTSLVGGMFALPRCV 342

  Fly   356 FAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCV 420
            |:|::|||||..|..::.|.:.|.:..:|.|.||.|:|.:|:::.||..:|||||||||:|::||
Worm   343 FSMADDGLLFSSLASVNPKTQVPTQALLIFGFLTAIIALLFDITTLVEFLSIGTLLAYSIVSACV 407

  Fly   421 LMLRYE----VDDRRESRIVANGRATGLEQDRP-CALWRRIFNLNGQTVPTKQTSRIVTYSVTLF 480
            ::|||:    ||   |.:....|:   |....| |....::           |....:.|.:::
Worm   408 IVLRYQPAYNVD---EGQFDNGGK---LRFSIPFCGFLDKL-----------QPGHSIYYGMSV- 454

  Fly   481 SLWCMVFSQILTKFEEDLANVTSFDGIKL----VLGTIPLAVLLLV-----------ISRQPTSG 530
                |:.|..             |.|:..    :.||:...:.|||           |.....:.
Worm   455 ----MIASMF-------------FSGLGFSSGYLYGTVLCQIFLLVNIALIILSFLFICAHYPNN 502

  Fly   531 VKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSR 586
            ..|.|||||||.:|.:|:|||..:|:.|..:||:|..:|::||..|:..|||.||:
Worm   503 TPLDFKVPLVPLIPALSLLINTLMMVHLAWITWLRLVVWMSIGFVIYFGYGIHHSK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	230/573 (40%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	24/49 (49%)
C50D2.2	NP_493662.1	2A0303	6..559	CDD:273330	232/576 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750