DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and aat-1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_501707.1	Gene:	aat-1 / 177793	WormBaseID:	WBGene00000002	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	127/572 - (22%)
Similarity:	214/572 - (37%)	Gaps:	173/572 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKPLED-------SNESK-----LAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVS 77
            |:||:.       .||::     |.|.|:.|:..::.:|..:|.|::|....|.:| || :|.:|
Worm     5 KEPLKSREGDEAPQNETEGKGKGLEKSLTLFNGVSMIVGCIIGSGIFVSPTGVQEQ-AG-SVGLS 67

  Fly    78 FLIAAIASIFAGL---CYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASV--- 136
            .::..|:.||..:   ||||.|..:.|:|..|.|.....|.|:||:..|  |....:...:|
Worm    68 LIVWLISGIFTAIGAYCYAELGTLIKKSGGDYAYIMEAFGPFVAFIRLW--IEAIVVRPCTVTIV 130

  Fly   137 -----VKGLSTYLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRV 196
                 :.||..:... |..|                ....:|.|.::.:|.:....:..:.:|.|
Worm   131 ALTFAIYGLRPFFPD-CAPP----------------DVVAELLAILLIVLMTAINCISVRLATIV 178

  Fly   197 NNVFTMLNLGVVLFVIIAGL-------------FKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGI 248
            .:.||:..:..:..:|:.||             |:....|.|...::|...:..|.|...|
Worm   179 QDWFTIAKVVALCLIILTGLGLLFFGESQYKDSFENIFENTSQDFTKVSLAFYSGLFAYSG---- 239

  Fly   249 IKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPY--FEQD 311
                    :.|:.|     ..||.:|||:::|.|:.:|:....:.|     |||.:..|  ...|
Worm   240 --------WNFLNF-----IVEELQNPKRNLPLAIAISITSCTVIY-----VLTNVALYTAISPD 286

  Fly   312 EKAPLPHVFRINGWHVAEYVVSIGAMFG-------LC------SSMMGAMFPLPRIVFAMSNDGL 363
            |....|          |..|:....::|       ||      .|..|.:|...|:.::.:.:|.
Worm   287 EMLESP----------AVAVLFANKLYGKFAFIMPLCVACSTIGSANGVIFTSARLFYSGAREGQ 341

  Fly   364 LFKFLGDISEKYKTPFKGTMITGMLT-GILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEV 427
            :...|..|::|.|||....::||.|: ..|.|..::.||:|.:.|...||.....:.:..||..:
Worm   342 MPAVLTMINKKTKTPIPAVILTGALSIAYLLASKDVYQLINYIQISYWLAIGTAIAALFWLRRTM 406

  Fly   428 DDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILT 492
            .|                ..||.            .||.               :|..:|
Worm   407 PD----------------ASRPI------------KVPL---------------IWPAIF----- 423

  Fly   493 KFEEDLANVTSFDGIKLVLGTIPLAV--------LLLVISRQPTSGVKLSFK 536
                 ||..     |.|||  ||:..        ||:::|..|..|:.:.:|
Worm   424 -----LAGC-----IALVL--IPMVAAPRDTGIGLLIMLSAVPVYGIFIGWK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	127/572 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	1/2 (50%)
aat-1	NP_501707.1	2A0308	2..491	CDD:273332	127/572 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920