DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and B0454.6

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_494428.1	Gene:	B0454.6 / 173650	WormBaseID:	WBGene00015197	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	217/579 - (37%)
Similarity:	345/579 - (59%)	Gaps:	29/579 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VTNAFRVLTRKKPLE-DSN-ESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVS 77
            |::.::.:||||..| ||: :|.|.:.|...|:|.|.:|..:|.|:|||.|.|.:..|||:::.|
Worm     2 VSHVWQAITRKKRFEGDSHLDSNLRRCLGLMDITFLALGQMMGAGIYVLTGTVVRNQAGPSIIFS 66

  Fly    78 FLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLST 142
            |.:|.||::.:...|||||||.|:|||||.|:|:..||..||::||.:.|||.||:|:|.:..|.
Worm    67 FALAGIAALLSAFSYAEFGARFPRAGSAYTYTYIGFGELWAFIVGWTIPLEYMIGNAAVARSWSA 131

  Fly   143 YLDQLCGNPM-SSFLGTHMPLNIEG--MGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLN 204
            |.|.:..|.: ::.:|....|:..|  ...|||:.:|::..|.:..||||.|.|..||:.|.:||
Worm   132 YFDNMLDNYIKNTTIGALGELSEPGGFFSTYPDILSFLLICLCACVIAVGPKVSANVNSSFVVLN 196

  Fly   205 LGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAG 269
            :.|:..||::|:.....:||:...|.     |...|.|:|::|.:.|||.||:.:|||:.:||||
Worm   197 IVVIFIVIVSGICYADFNNWTGTTSD-----GRSMFFPFGLTGTLTGAATCFFSYIGFEVLATAG 256

  Fly   270 EEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSI 334
            ||.|:|.::||.|..:|:.:|...|..||:.||:|:||.:....||....|...|.....|::||
Worm   257 EEVKSPHRTIPVATFLSIGVIMTLYILVSSTLTLMVPYDQVHTTAPFAEAFSARGCTTVMYIISI 321

  Fly   335 GAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLS 399
            ||:.||.::::..:|.|||.|:||::|||:||:|..::...|.|....:|..:|..|:|.:|::.
Worm   322 GALIGLTNNLVTGVFALPRAVYAMADDGLIFKWLAHVTSSTKVPLNAIVIFTLLNAIIALIFDIE 386

  Fly   400 QLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTV 464
            .||..:|||||.|||.|:..||:|||:     .:.|..:|:.  ::.....:.|....|. .:::
Worm   387 ALVEFLSIGTLFAYSFVSGSVLVLRYQ-----SAPIDGDGKR--MDNGGELSSWIPARNF-WESL 443

  Fly   465 PTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTS--FDGIKLVLGTIPLAVLLLVISRQP 527
            |. .||..:..:..:.|.:.:.|: ..|.|.|......|  |:|:.:||      |:..::..|.
Worm   444 PA-GTSISLGVAALIGSFFWLAFT-FRTGFYEHWYGQISIGFNGLLIVL------VMAFILGHQQ 500

  Fly   528 TSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSR 586
            .| ::.|||||.||:||.:|:|:|:::|..|...||||..:|:.:||.|:.:||||||:
Worm   501 NS-LETSFKVPFVPFLPCLSLLVNVFMMAYLTTATWIRLFVWMGVGLLIYFSYGIRHSK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	214/571 (37%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	25/49 (51%)
B0454.6	NP_494428.1	2A0303	7..559	CDD:273330	216/574 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.600