DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and aat-5

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_491002.2	Gene:	aat-5 / 171814	WormBaseID:	WBGene00000006	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	84/411 - (20%)
Similarity:	171/411 - (41%)	Gaps:	73/411 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TALGIGSTLGVGVYVLAGEVSKQY--AGPAVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIY 108
            |:..||:.:|.|:::....:.:..  .|.:::: :::.|:.:|...:||.|.|..:.:||..:.|
Worm    13 TSYVIGNIIGSGIFITPASILRNVDSIGLSLLI-WVLCAVIAILGAICYIELGTSIREAGCDFAY 76

  Fly   109 SYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTY--LDQLCGNPMSSFLGTHMPLNIEGMGAYP 171
            ........|||...|             |..|.||  ...:|......:|       |||:..|.
Worm    77 ICYVKWYSIAFAFMW-------------VSVLMTYPATIAICAETFGQYL-------IEGLKQYY 121

  Fly   172 D-----------LFA----FVVTIL--FSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKV 219
            :           |||    |:||.:  |.|     :|.:.|...:.|:..|...:.:|..|.:..
Worm   122 EIDDALVPTCQKLFAYSLLFLVTWMNFFEL-----SKFAARFQILATIAKLFSCMLIIGTGFYFY 181

  Fly   220 SSSNWSIPKSQVPEGYGDGGFM--PYGVSGIIKGAAVCFYG----FIGFDCIATAGEEAKNPKKS 278
            ....|        .||.:....  .||...:|.|    |||    |.|:|.:..:..|.|:||::
Worm   182 FVKGW--------HGYLENPMQGSKYGTGNLILG----FYGGLWAFSGWDVLNYSTGEIKHPKRN 234

  Fly   279 IPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMFG--LC 341
            :|||::..::::...|..::....::|......:...:..:|  :...:.::...:..:.|  |.
Worm   235 VPFALLTGISVVTAIYVAINVAYFVVLDVETVKQSDAVAAIF--SRETLGDFANVVPFLIGILLI 297

  Fly   342 SSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMS 406
            .|:...:|...|.::|.:..|.|......::.:.::|....:...:|..:::.:.:|..|:..:.
Worm   298 GSLNSNLFSGSRYMYAAARQGHLPACFSCVNTETESPRVAVLAQSVLALVISYIGDLDTLITYVM 362

  Fly   407 IG--TLLAYSMVASCVLMLRY 425
            .|  ....:|:||  :|::|:
Worm   363 FGFWAQRIFSLVA--LLIIRH 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	84/411 (20%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
aat-5	NP_491002.2	2A0308	6..462	CDD:273332	84/411 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950