DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and Slc7a12

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	419	Identity:	86/419 - (20%)
Similarity:	169/419 - (40%)	Gaps:	65/419 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAA---IASIFAGLCYAEFG 96
            :|.:.|..|.::.:...:|||.|::|....|.| |:...:.||..|.|   :.||.:.||.||..
Mouse     2 QLLRALGVFHVSMILFSATLGTGIFVTPKAVLK-YSSLNIPVSLSIWAGCGLLSIMSALCNAEIA 65

  Fly    97 ARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQLC---GNPMSSFLGT 158
            ...|.:|::|.:...|:|..:|||..|..:..:.:|..:....::|.:.| |   |.|.
Mouse    66 TTYPLSGASYYFLKRTLGSSVAFLSLWIKLFAHFLGIGAQCLLIATSVIQ-CFYSGCPA------ 123

  Fly   159 HMPLNIEGMGAYPDL----FAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKV 219
                        |:|    .|..:...|.:..|.|.|.....|.|.:.:.|.|:..:.:..|. |
Mouse   124 ------------PELPTKCLALAILWSFGIVSARGIKTVAWFNTVSSFIKLSVLCLISLTVLL-V 175

  Fly   220 SSSNWSIPK------SQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKS 278
            :....::.:      :::|           ..|.|........|.::|...:.....|.|.|.::
Mouse   176 NGKKENVSRFENALDAELP-----------NASQIADAILQVSYSYLGSSVLIVIAGEIKRPTET 229

  Fly   279 IPFAVIVSLAMIFLAYF--GVS--TVLTMMLPYFEQDEKAP-LPHVFRINGWHVAEYVVSIGAMF 338
            ||..:|..::::.:.|.  .:|  .|||.....|....... :..||....| ::.:::|...:.
Mouse   230 IPKTLIYGISIVTVLYLLTNISYLAVLTSQEIIFSDSVGVTWMNRVFPSIQW-ISSFLISAFLLG 293

  Fly   339 GLCSSMMGAMFPLPRIVFAMSNDG---LLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQ 400
            .:...::.|    .|:.::.|.:|   .::..|.|    :.:|....:...:|:.:.....::..
Mouse   294 SVSCGIVSA----SRVFYSASQEGEFPSIYSMLND----HHSPAVADIQIVILSSVAIISSSIIY 350

  Fly   401 LVNMMSIGTLLAYSMVASCVLMLRYEVDD 429
            ||..:|:|:.....:....:|.:||:..|
Mouse   351 LVKYVSLGSFCINLLQMIGLLKIRYQNPD 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	86/419 (21%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	85/414 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930