DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and Slc7a3

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001288769.1	Gene:	Slc7a3 / 11989	MGIID:	1100521	Length:	618	Species:	Mus musculus

Alignment Length:	614	Identity:	268/614 - (43%)
Similarity:	383/614 - (62%)	Gaps:	52/614 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WSVTNAF-RVLTRKKPLE-DSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVV 75
            |.....| :.|.|::.|| ...|::||:.||..||.|||:|||||.|||||||||:|..|||::|
Mouse     3 WQALRRFGQKLVRRRVLELGMGETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIV 67

  Fly    76 VSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGL 140
            :.||:||::|:.|||||||||||||.:||||:|||||:||..||..||||||.|.||:|||.:..
Mouse    68 ICFLVAALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAW 132

  Fly   141 STYLDQLCGNPMSSFL-GTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLN 204
            |:..|.|.||.:|..| ||.:......:..|||.||..:.:|.:..:.:||.:|..|..|||.:|
Mouse   133 SSAFDNLIGNHISRTLKGTILLKMPHVLAEYPDFFALALVLLLTGLLVLGASKSALVTKVFTGMN 197

  Fly   205 LGVVLFVIIAGLFKVSSSNWSIPKSQVPEGY----------------GDGGFMPYGVSGIIKGAA 253
            |.|:.||||:|..|....||.:.|    |.|                |.|||||:|:.||::|||
Mouse   198 LLVLSFVIISGFIKGELRNWKLTK----EDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAA 258

  Fly   254 VCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPH 318
            .|||.|:|||||||.||||:||::|||..:::|:.:.||||||||:.||:|:||::...::|||.
Mouse   259 TCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISMFICFLAYFGVSSALTLMMPYYKLHPESPLPE 323

  Fly   319 VFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTM 383
            .|...||..|.|:|:||::..|.:|::|:|||:||::::|:.|||||:.|..:......|...|:
Mouse   324 AFSYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVMYSMAEDGLLFRVLAKVHSVTHIPIVATL 388

  Fly   384 ITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRR---ESRIVANGRATGLE 445
            ::|::...:|.:|.|:.||::||||||||:|:|:.|||:|||:.|...   |..:.........|
Mouse   389 VSGVIAAFMAFLFELTDLVDLMSIGTLLAHSLVSICVLILRYQPDQEMKSVEEEMELQEETLEAE 453

  Fly   446 QDRPCALWRRIFNLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLAN-----VTSFD 505
            :....||:..:     .::||..:.|:|....:|.::...|...:||.:...|.:     ||.
Mouse   454 KLTVQALFCPV-----NSIPTLLSGRVVYVCSSLLAVLLTVLCLVLTWWTTPLRSGDPVWVTV-- 511

  Fly   506 GIKLVLGTIPLAVLLLVIS----RQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRF 566
             :.|:||      |:|.||    |||.:...|.||||.||.||.:||.:|:|||:::...||.||
Mouse   512 -VVLILG------LILAISGVIWRQPQNRTPLHFKVPAVPLLPLVSIFVNVYLMMQMTAGTWARF 569

  Fly   567 SIWIAIGLAIFLAYGIRHSRLRQREQRNN 595
            .||:.||.||:..|||:||   .:|.:|:
Mouse   570 GIWMLIGFAIYFGYGIQHS---MKEVKNH 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	262/594 (44%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	27/49 (55%)
Slc7a3	NP_001288769.1	2A0303	4..588	CDD:273330	263/601 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847694
Domainoid	1	1.000	453	1.000	Domainoid score	I498
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1198
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8730
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.790