DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and SLC7A9

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001119807.1	Gene:	SLC7A9 / 11136	HGNCID:	11067	Length:	487	Species:	Homo sapiens

Alignment Length:	492	Identity:	110/492 - (22%)
Similarity:	211/492 - (42%)	Gaps:	89/492 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKPLED-----SNESK---LAKVLSAFDLTALGIGSTLGVGVYVLAGEV--SKQYAGPAVVVSFL 79
            :|..||     |.|.|   |.|.|......::.:|:.:|.|::|....|  :.:..||.:::...
Human     7 RKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAA 71

  Fly    80 IAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGW-NLILEYAIGSASVVKGLSTY 143
            ...:|::.| ||:||.|..:.|:|..|.|.....|...|:|..| :||:......|.:....|.|
Human    72 CGVLATLGA-LCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEY 135

  Fly   144 LDQLCGNPMSSFLGTHMP-LNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGV 207
               :|. |.  ::|...| :.::.:.|...||   ::.:.||::.:|    :.|.|:||...|.:
Human   136 ---VCA-PF--YVGCKPPQIVVKCLAAAAILF---ISTVNSLSVRLG----SYVQNIFTAAKLVI 187

  Fly   208 VLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFY----GFIGFDCIATA 268
            |..:||:||..::..|        .:.: |..|  .|....:...::.||    .:.|::.:...
Human   188 VAIIIISGLVLLAQGN--------TKNF-DNSF--EGAQLSVGAISLAFYNGLWAYDGWNQLNYI 241

  Fly   269 GEEAKNPKKSIPFAVIVSLAMIF-------LAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWH 326
            .||.:||.:::|.|:|:.:.::.       ::||.|.|...::     |.:...:....|:  .:
Human   242 TEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELL-----QSQAVAVTFGDRV--LY 299

  Fly   327 VAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGI 391
            .|.::|.:...|....:..|..|...|:::....:|.:.|.|..||.:..||....:..|::..|
Human   300 PASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATI 364

  Fly   392 LAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRI 456
            .....:::.|||..|....|.|.:....::::|:                |..|.:||.
Human   365 YIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF----------------TRKELERPI------ 407

  Fly   457 FNLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTK 493
                  .||.     ::...:||.|:: :|.:.|::|
Human   408 ------KVPV-----VIPVLMTLISVF-LVLAPIISK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	110/492 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
SLC7A9	NP_001119807.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/14 (36%)
SLC7A9	NP_001119807.1	2A0308	26..484	CDD:273332	104/473 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850