DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and slc7a8a

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001258826.1	Gene:	slc7a8a / 100007704	ZFINID:	ZDB-GENE-121120-2	Length:	531	Species:	Danio rerio

Alignment Length:	534	Identity:	119/534 - (22%)
Similarity:	199/534 - (37%)	Gaps:	101/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAKVLSAFDLTALGIGSTLGVGVYVLAGEV--SKQYAGPAVVVSFLIAAIASIFAGLCYAEFGAR 98
            |.|.:.......:.:|:.:|.|::|....|  :....|.|::|..|...|.:|.| |||||.|..
Zfish    35 LKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENASSVGLALIVWILTGIITAIGA-LCYAELGVT 98

  Fly    99 VPKAGSAYIYSYVTIGEFIAFLIGWNLILE-YAIGSASVVKGLSTYLDQLCGNPMSSFLGTHMPL 162
            :||:|..|.|.....|....||..|..:|. |....|.:....|.|:.|              ||
Zfish    99 IPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQ--------------PL 149

  Fly   163 NIEGMGAYPDLF---------AFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFK 218
                   :|..|         |.:..:|.:.......:.:|||.:|||...|..::.:||.|:.:
Zfish   150 -------FPTCFPPENGLRILAAICLLLLTWVNCSSVRWATRVQDVFTAGKLLALILIIIMGIVQ 207

  Fly   219 VSSSN--WSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCF----YGFIGFDCIATAGEEAKNPKK 277
            :....  |..|.:....      |..|.| |:|   |:.|    :.:.|::.:....||..:|..
Zfish   208 ICKGEYYWLEPANAFEP------FQDYDV-GLI---ALAFLQGSFAYGGWNFLNYVTEELVDPYV 262

  Fly   278 SIPFAVIVSLAMIFLAY-FGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMFGLC 341
            ::|.|:.:|:.::...| |.....:|.|.|. |......:...|......|..:::.|.......
Zfish   263 NLPRAIFISIPLVTFVYVFANIAYVTAMSPQ-ELLASNAVAVTFGEKLLGVMSWIMPISVALSTF 326

  Fly   342 SSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMS 406
            ..:.|::|...|:.||.:.:|.|...|..|..|..||....:.|.:.|.::....::..|:|.:.
Zfish   327 GGVNGSLFTSSRLFFAGAREGHLPSLLAMIHVKRCTPIPALLFTCISTLLMLCTSDMYTLINYVG 391

  Fly   407 IGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCAL-----------WR--RIFN 458
            ....|.|.:..:..::||.:..|                ..||..:           |.  .||:
Zfish   392 FINYLFYGVTVAGQIVLRIKQPD----------------MHRPIKISLVWPVIYLLFWAFLLIFS 440

  Fly   459 LNGQTVPTKQTSRIVTYSVTLFSL---W-----C------------MVFSQILTKFEEDLANVTS 503
            |..:.|.......|:...|.::.|   |     |            ..|..::...||......|
Zfish   441 LYSEPVVCGIGLAIMLTGVPVYFLGVYWDNKPQCFNTFVDKMTYLGQKFCVVVYPMEEVKKTDES 505

  Fly   504 FDGIKLVLGTIPLA 517
            .:||:|...|.||:
Zfish   506 AEGIELKEQTAPLS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	119/534 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
slc7a8a	NP_001258826.1	2A0308	1..497	CDD:273332	110/510 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850