DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpRS-m and WARS1

DIOPT Version :9

Sequence 1:NP_001262001.1 Gene:TrpRS-m / 39989 FlyBaseID:FBgn0036763 Length:665 Species:Drosophila melanogaster
Sequence 2:NP_004175.2 Gene:WARS1 / 7453 HGNCID:12729 Length:471 Species:Homo sapiens


Alignment Length:387 Identity:75/387 - (19%)
Similarity:137/387 - (35%) Gaps:116/387 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 QVTGGNKQHVHPHG-----NSVNSGHEEHNTRWPRKVFSGIQPTG-SLHLGNYLGAV-RKWVQ-- 106
            :.||....|....|     ..:|...:.:..:.|..:::|..|:. ::|:|:.:..: .||:|  
Human   122 RATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDV 186

  Fly   107 -----LQNARDDVTVCIVDLHSITMPHNPPLLRENIFTMAATLLACGIDPTKSTLF-------VQ 159
                 :....||......||   |:........||    |..::|||.|..|:.:|       :.
Human   187 FNVPLVIQMTDDEKYLWKDL---TLDQAYSYAVEN----AKDIIACGFDINKTFIFSDLDYMGMS 244

  Fly   160 SA-------VAEHAEFNWI--LSSLT--------TMPRLAQLPQFREK-SRLLKDVPLGLYVYPV 206
            |.       :.:|..||.:  :...|        :.|.:...|.|... .::.:|          
Human   245 SGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRD---------- 299

  Fly   207 LQAADIMLYKSTHVPVGADQIQHIQLAQHLARIYNGRYGETFPVCTAIIEDGDASRVLSLRDPSK 271
              ..||...    :|...||..:.::.:.:|    .|.|...|   |::.   ::...:|:....
Human   300 --RTDIQCL----IPCAIDQDPYFRMTRDVA----PRIGYPKP---ALLH---STFFPALQGAQT 348

  Fly   272 KMSKSEANPKATINLCDSPDLITQKIKKAVTDFTSDITYNPGKRAGVSNLVNIHAQVTG------ 330
            |||.|:  |.::|.|.|:...|..|:.|...             :|..:.:..|.|..|      
Human   349 KMSASD--PNSSIFLTDTAKQIKTKVNKHAF-------------SGGRDTIEEHRQFGGNCDVDV 398

  Fly   331 ---------------QSIKTVVNEAATLDTAKYKDRVAEAVVEHLRPIREQIHHHMTKRNEM 377
                           :.|:......|.| |.:.|    :|::|.|:|:   |..|..:|.|:
Human   399 SFMYLTFFLEDDDKLEQIRKDYTSGAML-TGELK----KALIEVLQPL---IAEHQARRKEV 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpRS-mNP_001262001.1 PRK00927 82..406 CDD:234866 69/351 (20%)
TrpRS_core 82..359 CDD:173903 62/331 (19%)
WARS1NP_004175.2 WEPRS_RNA 12..61 CDD:238473
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..79
PLN02486 85..466 CDD:178104 75/387 (19%)
'HIGH' region 164..173 2/8 (25%)
'KMSKS' region 349..353 3/3 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0180
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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