DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpRS-m and Wars2

DIOPT Version :9

Sequence 1:	NP_001262001.1	Gene:	TrpRS-m / 39989	FlyBaseID:	FBgn0036763	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001162112.1	Gene:	Wars2 / 690654	RGDID:	1593417	Length:	360	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	179/386 - (46%)
Similarity:	245/386 - (63%)	Gaps:	29/386 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AVYSQRRCIQARSFLPGLASRTAGTPSATAQVTGGNKQHVHPHGNSVNSGHEEHNTRWPRKVFSG 85
            |::|.|:..:...|:..|..    .|:|||.          |...|            ..:||||
  Rat     2 ALFSVRKARECWRFIRALHK----GPTATAA----------PQKES------------GERVFSG 40

  Fly    86 IQPTGSLHLGNYLGAVRKWVQLQNARDDVTVCIVDLHSITMPHNPPLLRENIFTMAATLLACGID 150
            |||||..||||||||:..||:||...|.|...||||||||:|.:|.:|:::|..|.|.|||||||
  Rat    41 IQPTGIPHLGNYLGAIESWVKLQEEYDTVIYSIVDLHSITVPQDPGILQQSILDMTAVLLACGID 105

  Fly   151 PTKSTLFVQSAVAEHAEFNWILSSLTTMPRLAQLPQFREK-SRLLKDVPLGLYVYPVLQAADIML 214
            |.:|.||.||.|:||.:.:|||:.:..:|||..|.|::.| :|...|..:||..|||||||||:.
  Rat   106 PERSILFQQSQVSEHTQLSWILTCMVRLPRLQHLHQWKAKAARQKHDGTVGLLTYPVLQAADILC 170

  Fly   215 YKSTHVPVGADQIQHIQLAQHLARIYNGRYGETFPVCTAIIEDGDASRVLSLRDPSKKMSKSEAN 279
            |||||||||.||:||::|.|.|||.:|.:|||.||:..:|:.  ...:|.||||||.|||||:.:
  Rat   171 YKSTHVPVGEDQVQHMELVQDLARSFNQKYGELFPLPRSILT--SMKKVKSLRDPSAKMSKSDPD 233

  Fly   280 PKATINLCDSPDLITQKIKKAVTDFTSDITYNPGKRAGVSNLVNIHAQVTGQSIKTVVNEAATLD 344
            ..||:.:.|||:.|.:|.:||||||||::||.|..|.||||:|.|||.|:|.|::.||..:|.:|
  Rat   234 KLATVQITDSPEEIVRKFRKAVTDFTSEVTYEPDSRPGVSNMVAIHAAVSGLSVEEVVRNSAGVD 298

  Fly   345 TAKYKDRVAEAVVEHLRPIREQIHHHMTKRNEMIYLLEVGAEKARQQARQTLNDVKQRLGL 405
            ||:||..||:||:|...|||.:|......::.:..:|.||:.||::.|.....:||:.:|:
  Rat   299 TARYKLLVADAVIEKFAPIRSEIEKLKMDKDHLRKVLLVGSAKAKELASPVFEEVKKLVGI 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS-m	NP_001262001.1	PRK00927	82..406	CDD:234866	168/325 (52%)
TrpRS-m	NP_001262001.1	TrpRS_core	82..359	CDD:173903	154/277 (56%)
Wars2	NP_001162112.1	PRK00927	35..360	CDD:234866	168/327 (51%)
Wars2	NP_001162112.1	TrpRS_core	36..312	CDD:173903	154/277 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341920
Domainoid	1	1.000	306	1.000	Domainoid score	I1314
eggNOG	1	0.900	-	-		E1_COG0180
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5673
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003309
OrthoInspector	1	1.000	-	-		oto95443
orthoMCL	1	0.900	-	-		OOG6_101334
Panther	1	1.100	-	-	LDO	PTHR43766
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2207
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.700