DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and IRC15

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_015308.1	Gene:	IRC15 / 856090	SGDID:	S000005938	Length:	499	Species:	Saccharomyces cerevisiae

Alignment Length:	476	Identity:	166/476 - (34%)
Similarity:	255/476 - (53%)	Gaps:	19/476 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DIVVIGSGPGGYVAAIKAAQMGMKTVSVEKEATLGGTCLNVGCIPSKALLNNSHYYHMAHSGDL- 102
            |::|||.||||:.||::|:|.|:.|..|::.|:|||..|..|.:|||.||..|:.|.:....:|
Yeast    19 DVLVIGCGPGGFTAAMQASQAGLLTACVDQRASLGGAYLVDGAVPSKTLLYESYLYRLLQQQELI 83

  Fly   103 EKRGISCGSVSLDLEKLMGQKSNAVKALTGGIAMLFKKNKVTQLTGFGTIVNPNEVEVKKSDGST 167
            |:||........|::.......:.::.|.........||.||...|.....:|:.||:.:.....
Yeast    84 EQRGTRLFPAKFDMQAAQSALKHNIEELGNVYKRELSKNNVTVYKGTAAFKDPHHVEIAQRGMKP 148

  Fly   168 ETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALKLAKVPKHLVVIGAGVIGLELGSVWSRLG 232
            ..|:.|.|::||||.|...||:.||.:.|:||..||.|..:|....::|.|.||||:..:::.||
Yeast   149 FIVEAKYIVVATGSAVIQCPGVAIDNDKIISSDKALSLDYIPSRFTIMGGGTIGLEIACIFNNLG 213

  Fly   233 AEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQGLKFKLGTKV-TAASRSGDNVTVSVENAKSGEK 296
            :.||.:|....| ...:|||::...:.:|..||:.|.|.|:| .|.:.:...:.:::.|..|.:.
Yeast   214 SRVTIVESQSEI-CQNMDNELASATKTLLQCQGIAFLLDTRVQLAEADAAGQLNITLLNKVSKKT 277

  Fly   297 EEIQCDALLVSVGRRPYTEGLGLEAVGIVKDDRGRIPVNATFQT----VVPNIYAIGDCIHGPML 357
            ....||.|:||:||||..:||.:.::|:  |:|..:. |...||    ..|:|..|||...||||
Yeast   278 YVHHCDVLMVSIGRRPLLKGLDISSIGL--DERDFVE-NVDVQTQSLLKYPHIKPIGDVTLGPML 339

  Fly   358 AHKAEDEGLITIEGINGGHVHIDYNC--VPSVVYTHPEVAWVGKSEEQLKQEGVAYKVGKFPFLA 420
            |.|||::.:..|:.|.........||  .|:|:|..|::.|||.:||.|.:..:.|:.|:..|..
Yeast   340 ALKAEEQAIRAIQSIGCTGSDGTSNCGFPPNVLYCQPQIGWVGYTEEGLAKARIPYQKGRVLFSQ 404

  Fly   421 NSRAKT------NNDTDGFVKVLADQATDKILGTHIIGPGAGELINEAVLAMEYGAAAEDVARVC 479
            |.|..|      |.....|:|||.|....||||.|:|...|.||:::|.:|:..|..|.||.:|.
Yeast   405 NVRYNTLLPREENTTVSPFIKVLIDSRDMKILGVHMINDDANELLSQASMAVSLGLTAHDVCKVP 469

  Fly   480 HAHPTCSEALREA-NVAAAFG 499
            ..||:.||:.::| .:|.|.|
Yeast   470 FPHPSLSESFKQAVQLAMANG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	166/476 (35%)
		NADB_Rossmann	35..>74	CDD:304358	17/34 (50%)
		Pyr_redox	211..290	CDD:278498	23/79 (29%)
		Pyr_redox_dim	385..491	CDD:280934	42/111 (38%)
IRC15	NP_015308.1	Lpd	18..482	CDD:224169	162/466 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S261
OMA	1	1.010	-	-		QHG60979
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22912
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.760