DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and txnrd3

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001340296.1	Gene:	txnrd3 / 779989	XenbaseID:	XB-GENE-973837	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	139/518 - (26%)
Similarity:	228/518 - (44%)	Gaps:	81/518 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SSTHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVE-----KEAT---LGGTCLNVGCIPSK---- 85
            |.|::.|::|||.|.||...:.:||..|.|.:.::     .:.|   |||||:||||||.|
Frog   107 SVTYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKLMHQ 171

  Fly    86 -ALLNNS----------HYYHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKALTGGIAMLFK 139
             |:|..|          :...:.|:.|..:..|                .|.:.:|..|..:..:
Frog   172 AAILGQSLKDSRKFGWEYEEQVKHNWDTMREAI----------------QNYIGSLNWGYRVSLR 220

  Fly   140 KNKVTQLTGFGTIVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALK 204
            ..:|.....:|..|.|::::.....|.......:..::||| |...:..|..|:|..::|.....
Frog   221 DKQVRYENAYGEFVEPHKIKATNKRGKESFFTAEKFVVATG-ERPRYLNIPGDKEYCITSDDLFS 284

  Fly   205 LAKVPKHLVVIGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQGLKF- 268
            |...|...:|:||..:.||.....:.||.:.|.:  :.:|...|.|.|::......:...|:||
Frog   285 LPYCPGKTLVVGASYVALECAGFLAGLGLDATVM--VRSILLRGFDQEMANRAGAYMETHGVKFI 347

  Fly   269 -----------KLGT----KVTAASRSGDNVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLG 318
                       :.||    ||||.:..||.:.            |.:.:.:|::|||...|..:|
Frog   348 KQFVPISVELLEEGTPGRLKVTAKATEGDQII------------EDEYNTVLIAVGRDACTRNIG 400

  Fly   319 LEAVGI-VKDDRGRIPVNATFQTVVPNIYAIGDCIHGPM-LAHKAEDEG-LITIEGINGGHVHID 380
            ||.:|: |.:..|:|||:...||.||.:|||||.:.|.: |...|...| |:......|..:..|
Frog   401 LEKIGVKVNERNGKIPVSDEEQTSVPYVYAIGDILDGKLELTPVAIQAGRLLARRLYKGSKLKCD 465

  Fly   381 YNCVPSVVYTHPEVAWVGKSEEQL-----KQEGVAYKVGKFPFLANSRAKTNNDTDGFVKVLAD- 439
            |..||:.|:|..|....|.:||:.     ::....|....:|......::.||..  |.|::.:
Frog   466 YVNVPTTVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDNNTC--FAKIICNK 528

  Fly   440 QATDKILGTHIIGPGAGELINEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPI 502
            |..|:::|.|::||.|||:......|::.|...|.:......||||:|.....:|:.:.|..|
Frog   529 QDDDRVVGFHVLGPNAGEITQGFGAAIKCGLTKEKLDETIGIHPTCAEVFTTMDVSKSSGGDI 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	138/516 (27%)
		NADB_Rossmann	35..>74	CDD:304358	14/46 (30%)
		Pyr_redox	211..290	CDD:278498	23/94 (24%)
		Pyr_redox_dim	385..491	CDD:280934	30/111 (27%)
txnrd3	NP_001340296.1	GRX_GRXh_1_2_like	21..102	CDD:239511
txnrd3	NP_001340296.1	TGR	110..598	CDD:273624	137/515 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010