DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and Txnrd1

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001035988.1	Gene:	Txnrd1 / 50493	MGIID:	1354175	Length:	613	Species:	Mus musculus

Alignment Length:	495	Identity:	139/495 - (28%)
Similarity:	235/495 - (47%)	Gaps:	39/495 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 THEADIVVIGSGPGGYVAAIKAAQMGMKTVSVE--------KEATLGGTCLNVGCIPSKALLNNS 91
            :::.|:::||.|.||..||.:||:...|.:.::        ....|||||:||||||.|.:
Mouse   124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM---- 184

  Fly    92 HYYHMAHSGDLEKRGISCG-----SVSLDLEKLMGQKSNAVKALTGGIAMLFKKNKVTQLTGFGT 151
              :..|..|...|...:.|     :|..|.||:.....:.:.:|..|..:..::.||.....:|.
Mouse   185 --HQAALLGQALKDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYENAYGR 247

  Fly   152 IVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALKLAKVPKHLVVIG 216
            .:.|:.:....:.|..:....:..||||| |...:.||..|:|..:||.....|...|...:|:|
Mouse   248 FIGPHRIVATNNKGKEKIYSAERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVG 311

  Fly   217 AGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQGLKF---KLGTKV--TA 276
            |..:.||.....:.:|.:||.:  :.:|...|.|.:::....:.:.:.|:||   .:.||:  ..
Mouse   312 ASYVALECAGFLAGIGLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIE 374

  Fly   277 ASRSGDNVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGI-VKDDRGRIPVNATFQT 340
            |...| .:.|:.::..|.|..|.:.:.:|::|||...|..:|||.||: :.:..|:|||....||
Mouse   375 AGTPG-RLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQT 438

  Fly   341 VVPNIYAIGDCIHGPM-LAHKAEDEGLITIEGINGG-HVHIDYNCVPSVVYTHPEVAWVGKSE-- 401
            .||.||||||.:.|.: |...|...|.:..:.:.|| :|..||:.||:.|:|..|....|.||
Mouse   439 NVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDYDNVPTTVFTPLEYGCCGLSEEK 503

  Fly   402 --EQLKQEGV-AYKVGKFPFLANSRAKTNNDTDGFVKVLADQATD-KILGTHIIGPGAGELINEA 462
              |:..:|.: .|....:|......::.||..  :.|::.:...| :::|.|::||.|||:....
Mouse   504 AVEKFGEENIEVYHSFFWPLEWTVPSRDNNKC--YAKIICNLKDDERVVGFHVLGPNAGEVTQGF 566

  Fly   463 VLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPI 502
            ..|::.|...:.:......||.|:|.....:|....|..|
Mouse   567 AAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGDI 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	139/495 (28%)
		NADB_Rossmann	35..>74	CDD:304358	12/46 (26%)
		Pyr_redox	211..290	CDD:278498	19/83 (23%)
		Pyr_redox_dim	385..491	CDD:280934	28/111 (25%)
Txnrd1	NP_001035988.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..121
		TGR	125..613	CDD:273624	139/494 (28%)
		Pyr_redox	306..382	CDD:278498	18/78 (23%)
		Pyr_redox_dim	485..595	CDD:280934	28/111 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820