DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7430 and Dld

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_955417.1	Gene:	Dld / 298942	RGDID:	735073	Length:	509	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	341/502 - (67%)
Similarity:	397/502 - (79%)	Gaps:	14/502 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRHVVSAVAKTPLRTNAAILGALNARCYSSTH-EADIVVIGSGPGGYVAAIKAAQMGMKTVSVEK 68
            |.|.:...:..||||            ||... :||:.|||||||||||||||||:|.|||.:||
  Rat    20 LSHGLQGASSVPLRT------------YSDQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK 72

  Fly    69 EATLGGTCLNVGCIPSKALLNNSHYYHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKALTGG 133
            ..|||||||||||||||||||||||||:||..|...|||....|.|:|||:|.||.:||||||||
  Rat    73 NETLGGTCLNVGCIPSKALLNNSHYYHLAHGKDFASRGIEIPEVRLNLEKMMEQKRSAVKALTGG 137

  Fly   134 IAMLFKKNKVTQLTGFGTIVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVS 198
            ||.|||:|||..:.|||.|...|:|....:||||:.:.||||||||||||||||||.|||:.|||
  Rat   138 IAHLFKQNKVVHVNGFGKITGKNQVTATTADGSTQVIGTKNILIATGSEVTPFPGITIDEDTIVS 202

  Fly   199 STGALKLAKVPKHLVVIGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTK 263
            |||||.|.|||:.||||||||||:||||||.||||:|||:||:..:||:|||.|:||.||::|.|
  Rat   203 STGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDMEISKNFQRILQK 267

  Fly   264 QGLKFKLGTKVTAASRSGD-NVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGIVKD 327
            ||.||||.||||.|::..| .:.||||.|..|:.|.|.||.|||.:||||:|:.||||.:||..|
  Rat   268 QGFKFKLNTKVTGATKKSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELD 332

  Fly   328 DRGRIPVNATFQTVVPNIYAIGDCIHGPMLAHKAEDEGLITIEGINGGHVHIDYNCVPSVVYTHP 392
            .:||||||..|||.:|||:||||.:.||||||||||||:|.:||:.||.|||||||||||:||||
  Rat   333 PKGRIPVNTRFQTKIPNIFAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHP 397

  Fly   393 EVAWVGKSEEQLKQEGVAYKVGKFPFLANSRAKTNNDTDGFVKVLADQATDKILGTHIIGPGAGE 457
            |||||||||||||:|||.:|||||||.||||||||.||||.||:|..::||:|||.||:||||||
  Rat   398 EVAWVGKSEEQLKEEGVEFKVGKFPFAANSRAKTNADTDGMVKILGHKSTDRILGAHILGPGAGE 462

  Fly   458 LINEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPINF 504
            ::|||.||:||||:.||||||||||||.|||.||||:||:|||||||
  Rat   463 MVNEAALALEYGASCEDVARVCHAHPTLSEAFREANLAASFGKPINF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	331/470 (70%)
		NADB_Rossmann	35..>74	CDD:304358	27/39 (69%)
		Pyr_redox	211..290	CDD:278498	52/79 (66%)
		Pyr_redox_dim	385..491	CDD:280934	82/105 (78%)
Dld	NP_955417.1	lipoamide_DH	43..508	CDD:273568	329/464 (71%)
		NADB_Rossmann	45..222	CDD:304358	126/176 (72%)
		Pyr_redox	215..288	CDD:278498	49/72 (68%)
		Pyr_redox_dim	390..496	CDD:280934	82/105 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352258
Domainoid	1	1.000	450	1.000	Domainoid score	I494
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84
Inparanoid	1	1.050	686	1.000	Inparanoid score	I673
OMA	1	1.010	-	-		QHG60979
OrthoDB	1	1.010	-	-		D283654at33208
OrthoFinder	1	1.000	-	-		FOG0003111
OrthoInspector	1	1.000	-	-		oto97419
orthoMCL	1	0.900	-	-		OOG6_100523
Panther	1	1.100	-	-	LDO	PTHR22912
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770