DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7430 and Txnrd3

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001171529.1	Gene:	Txnrd3 / 232223	MGIID:	2386711	Length:	652	Species:	Mus musculus

Alignment Length:	513	Identity:	143/513 - (27%)
Similarity:	231/513 - (45%)	Gaps:	73/513 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 STHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVE-----KEAT---LGGTCLNVGCIPSKALLNN 90
            |.|:.|:::||.|.||...|.:||.:|.|.:.::     .:.|   |||||:||||||.|.:
Mouse   162 SAHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLM--- 223

  Fly    91 SHYYHMA----HS-GDLEKRGISCG-SVSLDLEKLMGQKSNAVKALTGGIAMLFKKNKVTQLTGF 149
                |.|    |: .|.:|.|.... .|..:.|.:.....:.:.:|..|..:..::..||.:..|
Mouse   224 ----HQAALLGHALQDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVNSF 284

  Fly   150 GTIVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALKLAKVPKHLVV 214
            |..|:.::::.....|..........:|||| |...:.||:.|:|..::|.....|...|...:|
Mouse   285 GEFVDLHKIKATNKKGQETFYTASKFVIATG-ERPRYLGIQGDKEYCITSDDLFSLPYCPGCTLV 348

  Fly   215 IGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGV---GIDNEVSKTFQKVLTKQGLKF-------- 268
            :||..:|||.....:.||.:||.:     :..|   |.|.|:::.....|.:||:||
Mouse   349 VGASYVGLECAGFLAGLGLDVTVM-----VRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPIL 408

  Fly   269 ----------KLGTKVTAASRSGDNVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVG 323
                      ||  ||.|.|..|......:.|            .:|:::||...|..:|||.:|
Mouse   409 VQQLEKGLPGKL--KVVAKSTEGPETVEGIYN------------TVLLAIGRDSCTRKIGLEKIG 459

  Fly   324 I-VKDDRGRIPVNATFQTVVPNIYAIGDCIHG-PMLAHKAEDEGLITIEGINGGHVH-IDYNCVP 385
            : :.:..|:||||...||.||::|||||.:.| |.|...|...|.:....:.|..:. .||..:|
Mouse   460 VKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIP 524

  Fly   386 SVVYTHPEVAWVGKSEEQ----LKQEGV-AYKVGKFPFLANSRAKTNNDTDGFVKVLADQ-ATDK 444
            :.|:|..|....|.|||:    .|:|.: .|....:|.......:.||..  :.|::.:: ..::
Mouse   525 TTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTC--YAKIICNKFDNER 587

  Fly   445 ILGTHIIGPGAGELINEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPI 502
            ::|.|::||.|||:......||:.|...:.:......||||.|......:..:.|..|
Mouse   588 VVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDI 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	142/512 (28%)
		NADB_Rossmann	35..>74	CDD:304358	14/46 (30%)
		Pyr_redox	211..290	CDD:278498	26/99 (26%)
		Pyr_redox_dim	385..491	CDD:280934	30/111 (27%)
Txnrd3	NP_001171529.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		GRX_GRXh_1_2_like	76..157	CDD:239511
		TGR	164..652	CDD:273624	142/511 (28%)
		Pyr_redox	347..421	CDD:278498	21/80 (26%)
		Pyr_redox_dim	524..634	CDD:280934	30/111 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810