DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and dld-1

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001255810.1	Gene:	dld-1 / 178387	WormBaseID:	WBGene00010794	Length:	495	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	349/475 - (73%)
Similarity:	395/475 - (83%)	Gaps:	2/475 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ARCYSSTHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVEKEATLGGTCLNVGCIPSKALLNNSHY 93
            ||.||:|.:||:||||.|||||||||||||:|||||.|||.||||||||||||||||||||||||
Worm    21 ARNYSNTQDADLVVIGGGPGGYVAAIKAAQLGMKTVCVEKNATLGGTCLNVGCIPSKALLNNSHY 85

  Fly    94 YHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKALTGGIAMLFKKNKVTQLTGFGTIVNPNEV 158
            .|||.. |...|||.| :.||:|.|:|..|||:||.|||||..|||.|||..:.||.|||.||.|
Worm    86 LHMAQH-DFAARGIDC-TASLNLPKMMEAKSNSVKQLTGGIKQLFKANKVGHVEGFATIVGPNTV 148

  Fly   159 EVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALKLAKVPKHLVVIGAGVIGLE 223
            :.||:|||.||:..:|||||:||||||||||.|||:.||||||||.|.:|||.:|||||||||||
Worm   149 QAKKNDGSVETINARNILIASGSEVTPFPGITIDEKQIVSSTGALSLGQVPKKMVVIGAGVIGLE 213

  Fly   224 LGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQGLKFKLGTKVTAASRSGDNVTVSV 288
            |||||.||||||||:||:..:||:|||.||||.||:.|||||.||.|.|||..||::|..:||.|
Worm   214 LGSVWQRLGAEVTAVEFLGHVGGMGIDGEVSKNFQRSLTKQGFKFLLNTKVMGASQNGSTITVEV 278

  Fly   289 ENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGIVKDDRGRIPVNATFQTVVPNIYAIGDCIH 353
            |.||.|:|:.::||.||||||||||||||||..|.|..|:|||:|||..|||.||:|:||||.|.
Worm   279 EGAKDGKKQTLECDTLLVSVGRRPYTEGLGLSNVQIDLDNRGRVPVNERFQTKVPSIFAIGDVIE 343

  Fly   354 GPMLAHKAEDEGLITIEGINGGHVHIDYNCVPSVVYTHPEVAWVGKSEEQLKQEGVAYKVGKFPF 418
            ||||||||||||::.:|||.||.|||||||||||||||||||||||:||||||||||||:|||||
Worm   344 GPMLAHKAEDEGILCVEGIAGGPVHIDYNCVPSVVYTHPEVAWVGKAEEQLKQEGVAYKIGKFPF 408

  Fly   419 LANSRAKTNNDTDGFVKVLADQATDKILGTHIIGPGAGELINEAVLAMEYGAAAEDVARVCHAHP 483
            :||||||||||.:||||||||:.||::||.|||||.|||:|.||.|||||||:|||||||||.||
Worm   409 VANSRAKTNNDQEGFVKVLADKQTDRMLGVHIIGPNAGEMIAEATLAMEYGASAEDVARVCHPHP 473

  Fly   484 TCSEALREANVAAAFGKPIN 503
            |.|||.||||:||..||.||
Worm   474 TLSEAFREANLAAYCGKAIN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	345/469 (74%)
		NADB_Rossmann	35..>74	CDD:304358	31/38 (82%)
		Pyr_redox	211..290	CDD:278498	54/78 (69%)
		Pyr_redox_dim	385..491	CDD:280934	87/105 (83%)
dld-1	NP_001255810.1	PRK06327	27..486	CDD:235779	339/460 (74%)
		NADB_Rossmann	29..>66	CDD:304358	30/36 (83%)
		Pyr_redox	201..279	CDD:278498	53/77 (69%)
		Pyr_redox_dim	375..481	CDD:280934	87/105 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165979
Domainoid	1	1.000	456	1.000	Domainoid score	I248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84
Inparanoid	1	1.050	695	1.000	Inparanoid score	I352
Isobase	1	0.950	-	0	Normalized mean entropy	S261
OMA	1	1.010	-	-		QHG60979
OrthoDB	1	1.010	-	-		D283654at33208
OrthoFinder	1	1.000	-	-		FOG0003111
OrthoInspector	1	1.000	-	-		oto18556
orthoMCL	1	0.900	-	-		OOG6_100523
Panther	1	1.100	-	-	LDO	PTHR22912
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.860