DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and DLD

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000099.2	Gene:	DLD / 1738	HGNCID:	2898	Length:	509	Species:	Homo sapiens

Alignment Length:	501	Identity:	337/501 - (67%)
Similarity:	396/501 - (79%)	Gaps:	12/501 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRHVVSAVAKTPLRTNAAILGALNARCYSSTHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVEKE 69
            :.|.:..::..||||.|           ....:||:.|||||||||||||||||:|.|||.:||.
Human    20 ISHGLQGLSAVPLRTYA-----------DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73

  Fly    70 ATLGGTCLNVGCIPSKALLNNSHYYHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKALTGGI 134
            .||||||||||||||||||||||||||||..|...|||....|.|:|:|:|.|||.|||||||||
Human    74 ETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGI 138

  Fly   135 AMLFKKNKVTQLTGFGTIVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSS 199
            |.|||:|||..:.|:|.|...|:|...|:||.|:.:.||||||||||||||||||.|||:.||||
Human   139 AHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSS 203

  Fly   200 TGALKLAKVPKHLVVIGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQ 264
            ||||.|.|||:.:|||||||||:||||||.||||:|||:||:..:||||||.|:||.||::|.||
Human   204 TGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268

  Fly   265 GLKFKLGTKVTAASRSGD-NVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGIVKDD 328
            |.||||.||||.|::..| .:.||:|.|..|:.|.|.||.|||.:||||:|:.||||.:||..|.
Human   269 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333

  Fly   329 RGRIPVNATFQTVVPNIYAIGDCIHGPMLAHKAEDEGLITIEGINGGHVHIDYNCVPSVVYTHPE 393
            |||||||..|||.:||||||||.:.||||||||||||:|.:||:.||.|||||||||||:|||||
Human   334 RGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPE 398

  Fly   394 VAWVGKSEEQLKQEGVAYKVGKFPFLANSRAKTNNDTDGFVKVLADQATDKILGTHIIGPGAGEL 458
            ||||||||||||:||:.||||||||.||||||||.||||.||:|..::||::||.||:||||||:
Human   399 VAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEM 463

  Fly   459 INEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPINF 504
            :|||.||:||||:.||:|||||||||.|||.||||:||:|||.|||
Human   464 VNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	329/469 (70%)
		NADB_Rossmann	35..>74	CDD:304358	27/38 (71%)
		Pyr_redox	211..290	CDD:278498	51/79 (65%)
		Pyr_redox_dim	385..491	CDD:280934	80/105 (76%)
DLD	NP_000099.2	Pyr_redox_dim	43..509	CDD:332164	328/465 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158277
Domainoid	1	1.000	453	1.000	Domainoid score	I507
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84
Inparanoid	1	1.050	688	1.000	Inparanoid score	I703
Isobase	1	0.950	-	0	Normalized mean entropy	S261
OMA	1	1.010	-	-		QHG60979
OrthoDB	1	1.010	-	-		D283654at33208
OrthoFinder	1	1.000	-	-		FOG0003111
OrthoInspector	1	1.000	-	-		oto90297
orthoMCL	1	0.900	-	-		OOG6_100523
Panther	1	1.100	-	-	LDO	PTHR22912
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R320
SonicParanoid	1	1.000	-	-		X2083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750