DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and Dld

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031887.2	Gene:	Dld / 13382	MGIID:	107450	Length:	509	Species:	Mus musculus

Alignment Length:	501	Identity:	338/501 - (67%)
Similarity:	398/501 - (79%)	Gaps:	12/501 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRHVVSAVAKTPLRTNAAILGALNARCYSSTHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVEKE 69
            :.|.:..|:..||||.|           ....|||:.||||||||||||||:||:|.|||.:||.
Mouse    20 ISHGLQGVSSVPLRTYA-----------DQPIEADVTVIGSGPGGYVAAIKSAQLGFKTVCIEKN 73

  Fly    70 ATLGGTCLNVGCIPSKALLNNSHYYHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKALTGGI 134
            .||||||||||||||||||||||||||||..|...|||....|.|:|||:|.||.:|||||||||
Mouse    74 ETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEIPEVRLNLEKMMEQKHSAVKALTGGI 138

  Fly   135 AMLFKKNKVTQLTGFGTIVNPNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSS 199
            |.|||:|||..:.|||.|...|:|...|:||||:.:.|||||:||||||||||||.|||:.||||
Mouse   139 AHLFKQNKVVHVNGFGKITGKNQVTATKADGSTQVIDTKNILVATGSEVTPFPGITIDEDTIVSS 203

  Fly   200 TGALKLAKVPKHLVVIGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQ 264
            ||||.|.|||:.||||||||||:||||||.||||:|||:||:..:||:|||.|:||.||::|.:|
Mouse   204 TGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDMEISKNFQRILQRQ 268

  Fly   265 GLKFKLGTKVTAASRSGD-NVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGIVKDD 328
            |.||||.||||.|::..| .:.||||.|..|:.|.|.||.|||.:||||:|:.||||.:||..|.
Mouse   269 GFKFKLNTKVTGATKKSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDP 333

  Fly   329 RGRIPVNATFQTVVPNIYAIGDCIHGPMLAHKAEDEGLITIEGINGGHVHIDYNCVPSVVYTHPE 393
            :||||||..|||.:||||||||.:.||||||||||||:|.:||:.||.|||||||||||:|||||
Mouse   334 KGRIPVNNRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPE 398

  Fly   394 VAWVGKSEEQLKQEGVAYKVGKFPFLANSRAKTNNDTDGFVKVLADQATDKILGTHIIGPGAGEL 458
            ||||||||||||:||:.:|:|||||.||||||||.||||.||:|..::||::||.||:||||||:
Mouse   399 VAWVGKSEEQLKEEGIEFKIGKFPFAANSRAKTNADTDGMVKILGHKSTDRVLGAHILGPGAGEM 463

  Fly   459 INEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGKPINF 504
            :|||.||:||||:.||:|||||||||.|||.||||:||||||||||
Mouse   464 VNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAAFGKPINF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	329/469 (70%)
		NADB_Rossmann	35..>74	CDD:304358	27/38 (71%)
		Pyr_redox	211..290	CDD:278498	51/79 (65%)
		Pyr_redox_dim	385..491	CDD:280934	78/105 (74%)
Dld	NP_031887.2	Pyr_redox_2	43..508	CDD:330998	326/464 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848674
Domainoid	1	1.000	452	1.000	Domainoid score	I507
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84
Inparanoid	1	1.050	690	1.000	Inparanoid score	I690
Isobase	1	0.950	-	0	Normalized mean entropy	S261
OMA	1	1.010	-	-		QHG60979
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	1	1.000	-	-		FOG0003111
OrthoInspector	1	1.000	-	-		oto93880
orthoMCL	1	0.900	-	-		OOG6_100523
Panther	1	1.100	-	-	LDO	PTHR22912
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R320
SonicParanoid	1	1.000	-	-		X2083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750