DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7430 and txnrd1

DIOPT Version :9

Sequence 1:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001243400.1	Gene:	txnrd1 / 100495372	XenbaseID:	XB-GENE-956002	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	139/500 - (27%)
Similarity:	228/500 - (45%)	Gaps:	54/500 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 STHEADIVVIGSGPGGYVAAIKAAQMGMKTVSVE--------KEATLGGTCLNVGCIPSKALLNN 90
            |.::.|::|||.|.||..|:.:||..|.|.:.::        .:..|||||:||||||.| |::.
Frog   164 SGYDYDLIVIGGGSGGLAASKEAANYGKKVLVLDFVTPTPLGTKWGLGGTCVNVGCIPKK-LMHQ 227

  Fly    91 SHYYHMAHSGDLEKRGISC-GSVSLDLEKLMGQKSNAVKALTGGIAMLFKKNKVTQLTGFGTIVN 154
            :.....|.. |.:|.|... .::..:.|.:.....|.:.:|.....:...:|.|....|:|..|.
Frog   228 AALLRQALK-DSQKYGWQIEDNIQHNWEIMTDSVLNYIGSLNFNYRVSLMQNNVKYENGYGEFVE 291

  Fly   155 PNEVEVKKSDGSTETVKTKNILIATGSEVTPFPGIEIDEEVIVSSTGALKLAKVPKHLVVIGAGV 219
            |:.::...|.|..:....:..||||| |...:.||..|:|..::|.....|...|...:|:||..
Frog   292 PHTIKSTNSRGKEKYFTAEKFLIATG-ERPRYLGIPGDKEYCITSDDLFSLPYCPGKTLVVGASY 355

  Fly   220 IGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQKVLTKQGLKF------------KLGT 272
            :.||.....:.||.:||.:  :.:|...|.|.:::....:.:.:.|:||            :.||
Frog   356 VALECAGFLAGLGLDVTVM--VRSILLRGFDQQMANMIGEYMEEHGVKFIKQCVPTKIEQIEAGT 418

  Fly   273 ----KVTAASRSGDNVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAVGI-VKDDRGRI 332
                |||:.:..|...|           ||.  :.:|:::||...|..:|||..|: :.:..|:|
Frog   419 PGRLKVTSQASDGAETT-----------EEY--NTVLLAIGRDACTRNIGLEIPGVKINEKTGKI 470

  Fly   333 PVNATFQTVVPNIYAIGDCIHGPM-LAHKAEDEGLITIEGING-GHVHIDYNCVPSVVYTHPEVA 395
            |||...||.||.||||||.:...: |...|...|.:....:.| ..|..||..||:.|:|..|..
Frog   471 PVNDEEQTNVPYIYAIGDVLQDKLELTPVAIQAGRLLARRLYGDSTVKCDYVNVPTTVFTPLEYG 535

  Fly   396 WVGKSEE----QLKQEGV-AYKVGKFPFLANSRAKTNNDTDGFVKVLAD-QATDKILGTHIIGPG 454
            ..|.|||    |.::|.: .|....:|......|:.||..  :.|::.: :...:::|.|::.|.
Frog   536 ACGLSEEHAIRQYEEENIEVYHSYFWPLEWTVPARDNNKC--YAKIICNLKDKGRVVGFHVLSPN 598

  Fly   455 AGELINEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFG 499
            |||:.....:|::.|...:.:......||.|:|......|....|
Frog   599 AGEITQGFAVAIKCGLTKDQLDNTIGIHPVCAEIFTTLTVTKRSG 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	137/498 (28%)
		NADB_Rossmann	35..>74	CDD:304358	13/46 (28%)
		Pyr_redox	211..290	CDD:278498	22/94 (23%)
		Pyr_redox_dim	385..491	CDD:280934	28/111 (25%)
txnrd1	NP_001243400.1	Thioredoxin_like	73..153	CDD:294274
		TGR	166..653	CDD:273624	137/497 (28%)
		Pyr_redox	347..423	CDD:278498	17/77 (22%)
		Pyr_redox_dim	525..635	CDD:280934	28/111 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010