DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED19 and MED19

DIOPT Version :9

Sequence 1:	NP_001287103.1	Gene:	MED19 / 39987	FlyBaseID:	FBgn0036761	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001304007.2	Gene:	MED19 / 219541	HGNCID:	29600	Length:	244	Species:	Homo sapiens

Alignment Length:	222	Identity:	99/222 - (44%)
Similarity:	128/222 - (57%)	Gaps:	23/222 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGL 76
            |...|.|||  |..|...::.|...    |...:....||||.|:|.|...||||..:|:|.|.|
Human    31 PPPPPAGGG--PGTAPPPTAATAPP----GADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNL 89

  Fly    77 HHTLTKFKEKKFKESLASFLQNIPGINDLI-THPVENSTLRSVIEKPPIGGKELLPLTPVQLAGF 140
            .....||..||.||.|::||.::||:.||. :|  :||:|||:||||||......|:|...||||
Human    90 EQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSH--DNSSLRSLIEKPPILSSSFNPITGTMLAGF 152

  Fly   141 RLHPGPLPEQYRTTYVTPARKHKNKHKKQKHKDGVTTGQESTLLDSAGLET-YEKKH-KKQKRHE 203
            |||.||||||.|..::.|.:| ||||   |||       :|...|....|| .:..| ||:|:.|
Human   153 RLHTGPLPEQCRLMHIQPPKK-KNKH---KHK-------QSRTQDPVPPETPSDSDHKKKKKKKE 206

  Fly   204 DDKERKKRKKEKKRKKKNQSPE-PGVG 229
            :|.|||::|||||:||...||: ||:|
Human   207 EDPERKRKKKEKKKKKNRHSPDHPGMG 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED19	NP_001287103.1	Med19	50..202	CDD:287279	73/154 (47%)
MED19	NP_001304007.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		8/24 (33%)
		Med19	63..233	CDD:287279	79/172 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..244		31/74 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159428
Domainoid	1	1.000	150	1.000	Domainoid score	I4392
eggNOG	1	0.900	-	-		E1_KOG4043
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4373
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48661
OrthoDB	1	1.010	-	-		D1484317at2759
OrthoFinder	1	1.000	-	-		FOG0006079
OrthoInspector	1	1.000	-	-		oto91291
orthoMCL	1	0.900	-	-		OOG6_107921
Panther	1	1.100	-	-	LDO	PTHR22536
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2633
SonicParanoid	1	1.000	-	-		X4380
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800