DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5567 and PHO13

DIOPT Version :9

Sequence 1:	NP_649015.2	Gene:	CG5567 / 39986	FlyBaseID:	FBgn0036760	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_010045.1	Gene:	PHO13 / 851362	SGDID:	S000002395	Length:	312	Species:	Saccharomyces cerevisiae

Alignment Length:	316	Identity:	107/316 - (33%)
Similarity:	160/316 - (50%)	Gaps:	33/316 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KVT------EWLAGFDSVITDCDGVLWIYGQALEGSVDVMNQLKGMGKSIYFCTNNSTKTRSELL 89
            |:|      |:|..:|:.:.|||||||:..|||..:::::|.||.:||.:.|.||||||:|....
Yeast    10 KITNKEIAQEFLDKYDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYT 74

  Fly    90 KKGVELGFHIKENGIISTAHATAAYLKRRNFSK------RVFVIGSEGITKELDAVGIQHTEVG- 147
            ||....|..:||..|.::.:|:|.|:  |:|.|      :|:|.|..||.:||..:|  :..:|
Yeast    75 KKFASFGIDVKEEQIFTSGYASAVYI--RDFLKLQPGKDKVWVFGESGIGEELKLMG--YESLGG 135

  Fly   148 -----PEPMKGSLAEFMAQHLKLDTDIGAVVVGFDEHFSFPKMMKAASYLNDPECLFVATNTDER 207
                 ..|...:.:.|:..  .||.|:..|:.|.|...::.::.....||......||.||.|..
Yeast   136 ADSRLDTPFDAAKSPFLVN--GLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDST 198

  Fly   208 FPMPNMIVPGSGSFVRAIQTCAERDPVVIGKPNPAICESLVTEKKIDPSRTLMIGDRANTDILLG 272
            ||......||:||.:.::...:.|.|...||||..:..|:::...:|.|:..|:|||.|||:..|
Yeast   199 FPQKGYTFPGAGSMIESLAFSSNRRPSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFG 263

  Fly   273 FNCGF-QTLLVGSGIHQLKDVERWKLSQD-PEEKKLIPDVYLPKLGDLLPSIVNSL 326
            ...|. .||||.|||.  .:....|:|.| |.     |..|:.||||:.....|.|
Yeast   264 VEGGLGGTLLVLSGIE--TEERALKISHDYPR-----PKFYIDKLGDIYTLTNNEL 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5567	NP_649015.2	PGP_euk	40..318	CDD:273635	100/291 (34%)
		Hydrolase_6	42..142	CDD:290083	43/105 (41%)
		Hydrolase_like	235..318	CDD:289983	32/84 (38%)
PHO13	NP_010045.1	HAD_Pase_UmpH-like	24..308	CDD:319813	101/296 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I1988
eggNOG	1	0.900	-	-		E1_COG0647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5513
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1038
Isobase	1	0.950	-	0	Normalized mean entropy	S1709
OMA	1	1.010	-	-		QHG60740
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	1	1.000	-	-		otm46746
orthoMCL	1	0.900	-	-		OOG6_100677
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X675
TreeFam	1	0.960	-	-
	14	13.710