DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5567 and Pgp

DIOPT Version :9

Sequence 1:	NP_649015.2	Gene:	CG5567 / 39986	FlyBaseID:	FBgn0036760	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001162623.1	Gene:	Pgp / 287115	RGDID:	1307773	Length:	321	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	121/308 - (39%)
Similarity:	187/308 - (60%)	Gaps:	12/308 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LELSSAKVTEWLAGFDSVITDCDGVLWIYGQALEGSVDVMNQLKGMGKSIYFCTNNSTKTRSELL 89
            :.||:.:....||..|:::.|||||||....|:.|:.:.:..|:..||.:.|.||||:|||:...
  Rat    14 VRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLGFITNNSSKTRTAYA 78

  Fly    90 KKGVELGF---HIKENG--IISTAHATAAYLKRRNF---SKRVFVIGSEGITKELDAVGIQHTEV 146
            :|...|||   ...|.|  :..||:.:|.||::|..   ..:.:|:||..:..||:|||:....|
  Rat    79 EKLRRLGFGGPMGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGV 143

  Fly   147 GPEPMKG-SLAEFMAQHLKLDTDIGAVVVGFDEHFSFPKMMKAASYLNDPECLFVATNTDERFPM 210
            ||:.:.| ..::::|  :.|:.|:.|||||||.|||:.|:.||..||..|:||.|.||.|.|.|:
  Rat   144 GPDVLHGDGPSDWLA--VPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPL 206

  Fly   211 PN-MIVPGSGSFVRAIQTCAERDPVVIGKPNPAICESLVTEKKIDPSRTLMIGDRANTDILLGFN 274
            .| ..:.|:|..|||::..|:|...:||||:..|.:.:..|..|:|.||:|:|||.:||||||..
  Rat   207 ENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGST 271

  Fly   275 CGFQTLLVGSGIHQLKDVERWKLSQDPEEKKLIPDVYLPKLGDLLPSI 322
            |..:|:|..:|:..|:||:..:.|....:||::||.|:..:.||||::
  Rat   272 CSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPAL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5567	NP_649015.2	PGP_euk	40..318	CDD:273635	113/287 (39%)
		Hydrolase_6	42..142	CDD:290083	40/107 (37%)
		Hydrolase_like	235..318	CDD:289983	33/82 (40%)
Pgp	NP_001162623.1	PGP_euk	28..315	CDD:273635	113/288 (39%)
		Hydrolase_6	31..139	CDD:290083	40/107 (37%)
		Hydrolase_like	232..315	CDD:289983	33/82 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343738
Domainoid	1	1.000	76	1.000	Domainoid score	I8796
eggNOG	1	0.900	-	-		E1_COG0647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5513
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3528
OMA	1	1.010	-	-		QHG60740
OrthoDB	1	1.010	-	-		D337140at33208
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	1	1.000	-	-		mtm9072
orthoMCL	1	0.900	-	-		OOG6_100677
Panther	1	1.100	-	-	LDO	PTHR19288
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X675
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770