DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5567 and pho2

DIOPT Version :9

Sequence 1:	NP_649015.2	Gene:	CG5567 / 39986	FlyBaseID:	FBgn0036760	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_596255.1	Gene:	pho2 / 2539960	PomBaseID:	SPBC15D4.15	Length:	298	Species:	Schizosaccharomyces pombe

Alignment Length:	299	Identity:	104/299 - (34%)
Similarity:	157/299 - (52%)	Gaps:	14/299 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ELSSAK-VTEWLAGFDSVITDCDGVLWIYGQALEGSVDVMNQLKGMGKSIYFCTNNSTKTRSELL 89
            :|||.| ..|::..||..:.|||||||...:.:.|..|.|..|:.:||.|.|.:|||||:|...:
pombe     4 KLSSPKEYKEFIDKFDVFLFDCDGVLWSGSKPIPGVTDTMKLLRSLGKQIIFVSNNSTKSRETYM 68

  Fly    90 KKGVELGFHIKENGIISTAHATAAYLK---RRNFSKRVFVIGSEGITKELDAVGIQHTEVGPEP- 150
            .|..|.|...|...|..:|:::|.|:|   :....|:|||:|..||..|||.||:.|.. |.:|
pombe    69 NKINEHGIAAKLEEIYPSAYSSATYVKKVLKLPADKKVFVLGEAGIEDELDRVGVAHIG-GTDPS 132

  Fly   151 MKGSLAEFMAQHLKLDTDIGAVVVGFDEHFSFPKMMKAASYLNDPECLFVATNTDERFPMPNMIV 215
            ::.:||....:.:..|..:|||:.|.|.|.::.|...|..||.||.|.|:.||.|..||.....:
pombe   133 LRRALASEDVEKIGPDPSVGAVLCGMDMHVTYLKYCMAFQYLQDPNCAFLLTNQDSTFPTNGKFL 197

  Fly   216 PGSGSFVRAIQTCAERDPVVIGKPNPAICESLVTEKKIDPSRTLMIGDRANTDILLGFNCGF-QT 279
            ||||:....:.....|.|.::|||...:.|:::.....|..:...:|||.||||....|... .:
pombe   198 PGSGAISYPLIFSTGRQPKILGKPYDEMMEAIIANVNFDRKKACFVGDRLNTDIQFAKNSNLGGS 262

  Fly   280 LLVGSGIHQLKDVERWKLSQDPEEKKLIPDVYLPKLGDL 318
            |||.:|:.:.:::    |.:|   ..::||.|:..|..|
pombe   263 LLVLTGVSKEEEI----LEKD---APVVPDYYVESLAKL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5567	NP_649015.2	PGP_euk	40..318	CDD:273635	97/282 (34%)
		Hydrolase_6	42..142	CDD:290083	42/102 (41%)
		Hydrolase_like	235..318	CDD:289983	23/83 (28%)
pho2	NP_596255.1	NagD	11..298	CDD:223720	100/292 (34%)
		Hydrolase_6	21..123	CDD:290083	41/101 (41%)
		Hydrolase_like	217..294	CDD:289983	23/83 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I2380
eggNOG	1	0.900	-	-		E1_COG0647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5513
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1198
OMA	1	1.010	-	-		QHG60740
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	1	1.000	-	-		otm47201
orthoMCL	1	0.900	-	-		OOG6_100677
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X675
TreeFam	1	0.960	-	-
	13	12.760