DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5577 and Pdxp

DIOPT Version :9

Sequence 1:	NP_001303369.1	Gene:	CG5577 / 39985	FlyBaseID:	FBgn0036759	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_064667.2	Gene:	Pdxp / 57028	MGIID:	1919282	Length:	292	Species:	Mus musculus

Alignment Length:	322	Identity:	96/322 - (29%)
Similarity:	152/322 - (47%)	Gaps:	54/322 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RGGAI-DLTGLSEEQVSEWLQSFDTVLCDGDGTIWQDDTAIAGAPDVVNALQDRFDKKVYLITNN 66
            ||.|: |:.|.::           .||.|.||.:|..:..:.|||:::..|. |..|....::||
Mouse     8 RGAALRDVLGQAQ-----------GVLFDCDGVLWNGERIVPGAPELLQRLA-RAGKNTLFVSNN 60

  Fly    67 GLKTRQELFERSQRLGF-HLPSDRHIISPTAA---IADYLVGSPKFDRTRHKVYVVGNAAIAREL 127
            ..:.|.||..|..|||| .|.:::...|...|   :...|.|.|.   ....|:|:|...:..||
Mouse    61 SRRARPELALRFARLGFAGLRAEQLFSSALCAARLLRQRLSGPPD---ASGAVFVLGGEGLRAEL 122

  Fly   128 RQRGIDSYGAGGTDELPPGDKWPDFVTREFGNPEAAKDVGAVVVGWDEYFSYCKMARAC-HILCS 191
            |..|:                      |..|:|.....|.||:||:||.||:.::..|| |:  .
Mouse   123 RAAGL----------------------RLAGDPGEDPRVRAVLVGYDEQFSFSRLTEACAHL--R 163

  Fly   192 NPDAAFLVTNRDAVHKYPSFC-IPGTGAFVAGIEACSEREALEMGKPNPLVLEPFIKAEGLRTER 255
            :||...:.|:||..|...... .||||:..|.:|..|.|:||.:|||:|.:.:...:...:...|
Mouse   164 DPDCLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCITEDFSVDPAR 228

  Fly   256 TLMIGDCLKIDVGFASNCGMLSLLVGTGRYNNLSDVRL-----EKDRLPQPDFYLPRLGDLL 312
            |||:||.|:.|:.|...|||.::|..|| .::|.:.:.     ::|.:|.  :|:..:.||:
Mouse   229 TLMVGDRLETDILFGHRCGMTTVLTLTG-VSSLEEAQAYLTAGQRDLVPH--YYVESIADLM 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5577	NP_001303369.1	PGP_euk	25..311	CDD:273635	89/296 (30%)
		Hydrolase_6	27..132	CDD:290083	34/108 (31%)
		Hydrolase_like	234..311	CDD:289983	23/81 (28%)
Pdxp	NP_064667.2	PGP_euk	18..286	CDD:273635	89/309 (29%)
		Hydrolase_6	22..128	CDD:290083	35/131 (27%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:24338687, ECO:0000269\|PubMed:25783190, ECO:0007744\|PDB:4BX2, ECO:0007744\|PDB:5AES	58..60		0/1 (0%)
		Hydrolase_like	206..286	CDD:289983	23/82 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60740
OrthoDB	1	1.010	-	-		D982374at2759
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920