DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5577 and C45E5.1

DIOPT Version :9

Sequence 1:	NP_001303369.1	Gene:	CG5577 / 39985	FlyBaseID:	FBgn0036759	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_500857.2	Gene:	C45E5.1 / 183469	WormBaseID:	WBGene00016664	Length:	303	Species:	Caenorhabditis elegans

Alignment Length:	299	Identity:	93/299 - (31%)
Similarity:	152/299 - (50%)	Gaps:	24/299 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEWLQSFDTVLCDGDGTIWQDDTAIAGAPDVVNALQDRFDKKVYLITNNGLKTRQELFERSQRLG 82
            |:.|.:|||.:.|.||.:|..|..|.||.:.:|.|.|..:|.|::.|||..||.::..::.:::.
Worm     9 SQLLSNFDTFVFDADGVLWTGDIPIPGAAEWINTLLDDPEKSVFITTNNSTKTLEQYMKKVKKMR 73

  Fly    83 FHLPSDRHIISPTAAIADYL-VGSPKFDRTRHKVYVVGNAAIARELRQ-RGIDSYGAGGTDELPP 145
            |......:::|||..:.||. ..|.||:  ...:|::|...:.:.|.: .|:..:|.|      |
Worm    74 FGRLGRENLLSPTIVLCDYFKQNSDKFE--NQYIYLIGVENLKKSLEEGGGVKCFGTG------P 130

  Fly   146 GDKWPDFVTREFGNPEAAKD--VGAVVVGWDEYFSYCKMARACHILCSNPDAAFLVTNRDAVH-- 206
            ..| .::...:|.|....|.  ..||||.:|.:|||.|:.:|.:.| ::|...|||.|.|:..
Worm   131 DHK-DNYTDGDFINEVDVKSKIPKAVVVSFDSHFSYPKLMKAANFL-ADPLVEFLVCNEDSTFPG 193

  Fly   207 KYPSFCIPGTGAFVAGIEACSEREA-LEMGKPNPLV---LEPFIKAEGLRTERTLMIGDCLKIDV 267
            ..|...:|.||.:.|.|:..|.|:. :..|||:..:   |:..::|....:|||:|.||.|..|:
Worm   194 PVPGMILPETGPWSAAIQNVSGRKPDIVFGKPHEQLANFLKSRVQAGKFNSERTVMFGDRLDTDM 258

  Fly   268 GFASNCGMLSLLVGTGRYNNLSDVRLEK---DRLPQPDF 303
            .|..|.|..::.:.|| .|.|.|:.|.:   :....|||
Worm   259 MFGKNNGFTTVWMQTG-VNTLLDIELARKNGESTKIPDF 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5577	NP_001303369.1	PGP_euk	25..311	CDD:273635	90/292 (31%)
		Hydrolase_6	27..132	CDD:290083	30/106 (28%)
		Hydrolase_like	234..311	CDD:289983	25/76 (33%)
C45E5.1	NP_500857.2	HAD-SF-IIA	18..274	CDD:273637	79/265 (30%)
		Hydrolase_6	18..121	CDD:290083	30/104 (29%)
		Hydrolase_like	221..284	CDD:289983	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166645
Domainoid	1	1.000	64	1.000	Domainoid score	I6688
eggNOG	1	0.900	-	-		E1_COG0647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60740
OrthoDB	1	1.010	-	-		D337140at33208
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.820