Protein Alignment Grd and glrba

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_068076972.1
• Gene: glrba / 83412
• ZFINID: ZDB-GENE-010410-2
• Length: 499
• Species: Danio rerio
• Alignment Length: 643
• Identity: 169/643 - (26%)
• Similarity: 266/643 - (41%)
• Gaps: 163/643 - (25%)

  Fly    41 LLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSL--SSSLPSSWLTQ- 102
            ||....||||.:                ..||:    .|...:.|:.|..:  .|.|.:..|.:
Zfish     8 LLKGLILLMLLV----------------QFSAE----EGGKPKKGKKGKQVICPSQLSAEDLDRV 52

  Fly   103 -SNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVD 166
             :|:.:||   |:.||..||:.|||:|.|.|...:|:|.:.|.|.|.|..|.|.::.:.||.|.|
Zfish    53 PANSTSNI---LNRLLMTYDSRIRPNFKGIPVEDKVNIFINSFGSIQETTMDYRVNIFLRQRWND 114

  Fly   167 KRLAF--EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTI 229
            .||..  :...|.|.:...|...:||||.:|.|.|.:..|.:|..|..:.|::||.||.|.||::
Zfish   115 PRLRLPTDFKSDALTVDPKMFQCLWKPDLFFANEKNANFHDVTQENILLFIFRNGDVLISMRLSV 179

  Fly   230 KAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLT 294
            ...||:.|..||||.|.|.::..||||||.|:::.| :...||.: :::.|.|||:      ...
Zfish   180 TLSCPLALQLFPMDTQYCKMQLESFGYTTKDLVFMW-QSGDPVQM-DEIALPQFDV------KQE 236

  Fly   295 DIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSG 359
            ||.|                               |...:...|||.
Zfish   237 DIKY-------------------------------ANCTKFYPGTGY------------------ 252

  Fly   360 STTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRV 424
                              |:.:.|.|.|:|.:|.:::.||.|..|:|||||:|||:|.:|:|.||
Zfish   253 ------------------YTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARV 299

  Fly   425 SLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYY---TKYGSGEC 486
            .|||.:||:::.......::||||||..|:|.::.....:.||:::::|||...   .|....|.
Zfish   300 PLGILSVLSLSSECTSLASELPKVSYVKAIDIWMIACLLYGFASLVEYAVVQVMLNSPKRIEAEK 364

  Fly   487 YFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRR 551
            ..:.|:..:...|::|...|:...|:..:.|:               .:.|.::.:|.::....:
Zfish   365 IKMAEKEKAREKENKTPAKTNSANGTGGTPIH---------------VSTLQVVENRCKKVCTSK 414

  Fly   552 HGLWS--MKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPP 614
            ..|.|  ..::|..        ||       |.|.:.......|.....|:.........:.:||
Zfish   415 SDLRSNDFSIVGSL--------PR-------DFELSNFDCYGKPIEVTDASGKPQNKNNKKPAPP 464

  Fly   615 TGGRRRMSYYRREEMEARRKGKRTPQYNSVSK-IDRASRIVFPLLFILINVFYWYGYL 671
                                   .|...|.:| :|..:|.:||..|:..||.||..||
Zfish   465 -----------------------KPVIPSAAKRVDLYARALFPFTFLFFNVIYWSVYL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	150/566 (27%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	62/169 (37%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
glrba	XP_068076972.1	LIC	53..498	CDD:455710	153/575 (27%)
		LGIC_ECD	80..265	CDD:475126	70/259 (27%)