Protein Alignment Grd and GLRA3

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 179/589 - (30%)
• Similarity: 253/589 - (42%)
• Gaps: 171/589 - (29%)

  Fly    86 EMGTSLSSSLPSSWLTQSNNHANISELLDNLL---RGYDNSIRPDFGGPPATIEVDIMVRSMGPI 147
            |..::.|.|.|.|          .|:.||.|:   .|||..|||:|.|||..:..:|.:.|.|.|
Human    30 ETDSARSRSAPMS----------PSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSI 84

  Fly   148 SEVDMTYSMDCYFRQSWVDKRLAF-EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNK 211
            :|..|.|.::.:.||.|.|.|||: |...|:|.|..|||..|||||.:|.|.|.:..|.:||.||
Human    85 AETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNK 149

  Fly   212 FVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAE 276
            .:||::||.||||.|||:...|||:|.:||||:|.|.::..|||||.:|:|:.|..| .||.:||
Human   150 LLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDE-APVQVAE 213

  Fly   277 DMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGL 341
            .:.|.||.|.:                        .||                          |
Human   214 GLTLPQFLLKE------------------------EKD--------------------------L 228

  Fly   342 KLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLV 406
            :.....:.||:                         ::.:.|.|||:|.||.:|||:|.|..|:|
Human   229 RYCTKHYNTGK-------------------------FTCIEVRFHLERQMGYYLIQMYIPSLLIV 268

  Fly   407 VLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQ 471
            :|||||||:|.:|...||:||||||||||.....:|..||||||..|:|.::.:...|:|:.:|:
Human   269 ILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLE 333

  Fly   472 FAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTR 536
            :|.|::.::..        :||
Human   334 YAAVNFVSRQH--------KEL------------------------------------------- 347

  Fly   537 LGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAA 601
                 .|.||.|..:...::::....|              .|.|||..:.|      .|..|..
Human   348 -----LRFRRKRKNKTEAFALEKFYRF--------------SDMDDEVRESR------FSFTAYG 387

  Fly   602 AQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFY 666
            .....||.....|.|....:....:...|.|:     ...:...|||..||..|||.|::.|:||
Human   388 MGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRK-----VFIDRAKKIDTISRACFPLAFLIFNIFY 447

  Fly   667 WYGY 670
            |..|
Human   448 WVIY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	172/562 (31%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	73/168 (43%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	178/587 (30%)