DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grd and Gabrq

DIOPT Version :9

Sequence 1:	NP_524131.1	Gene:	Grd / 39984	FlyBaseID:	FBgn0001134	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_065234.1	Gene:	Gabrq / 57249	MGIID:	1888498	Length:	638	Species:	Mus musculus

Alignment Length:	682	Identity:	163/682 - (23%)
Similarity:	270/682 - (39%)	Gaps:	189/682 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LSSSLPSSWLTQSN-----NHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEV 150
            ||||.|...|...|     |.|.:.::||.:|..||..:||:|||.|..:.|.|.|.|:..|||:
Mouse    36 LSSSTPEVILDLFNCKNCANEAVVQKILDRVLSTYDVRLRPNFGGAPVPVSVSIYVSSIEQISEI 100

  Fly   151 DMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRI 215
            :|.|::..:..|:|.|.|||:......|.|...|..::|.||.||.|.|.:::|.:|..|:..::
Mouse   101 NMDYTITMFLHQTWKDTRLAYYETNLNLTLDYRMHEKLWVPDCYFVNSKDAFVHDVTVENRVFQL 165

  Fly   216 YQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKL 280
            :.:|.|.|..|||..|.|.::|..||||.|.|.|:..|:|||..|::..|..:. .:.|.:.:.:
Mouse   166 HPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDN-AIHITDGLHI 229

  Fly   281 SQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDK 345
            .|:                                         |:.|....::.|
Mouse   230 PQY-----------------------------------------TYLGRTITSKEV--------- 244

  Fly   346 GAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSW 410
             .|.||                         .|..|:|.|.:||.:.::|:|||.|..|..:|||
Mouse   245 -YFYTG-------------------------SYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSW 283

  Fly   411 VSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVV 475
            :|||:|.:::|.||::|:|::|.:|.:....|..||.:|...|:|.::.:...|:|.::|::..:
Mouse   284 ISFWMNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYI 348

  Fly   476 HY--------------------YTKYGSGECYF---------IIEELDSESGESETEPL-----T 506
            :|                    ..:|...|...         :.:.::..:|.....|:     :
Mouse   349 NYLFFSQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLAS 413

  Fly   507 SDFRGS---TESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRR----------HG-LWSM 557
            .:..||   |..:.......|:..:|.....|:|....|.:..|....          || |.:.
Mouse   414 QESLGSLVFTSEQAQLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTND 478

  Fly   558 KLLGLFDWRRRRKPPRADSDEDEDDEQ----------------------TQLRANEAP------- 593
            .::.:      :...|:|:.:|||.|:                      :|....||.
Mouse   479 SIIPI------KIHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQRCVQEASWDLDKIE 537

  Fly   594 --------TTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTP----------- 639
                    |:|......|....|..|...| ....|:..:.::..:..:...:|
Mouse   538 ILQDDISITSSWLGLDEQCKGDADSIWSLT-DEELMACDQEKDSSSESEENCSPSPGCSFNEGFS 601

  Fly   640 ----QYNSVSKIDRASRIVFPLLFILINVFYW 667
                :.|.|.|:||.||.:|||.|.|.||.||
Mouse   602 FQLFKPNRVPKVDRWSRFLFPLSFGLFNVVYW 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	63/215 (29%)
		LIC	111..670	CDD:273305	154/657 (23%)
		Neur_chan_memb	398..667	CDD:280999	75/368 (20%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	64/257 (25%)
		Cys-loop	183..197	CDD:349804	7/13 (54%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	30/98 (31%)
		TM1 helix	266..289	CDD:349858	12/22 (55%)
		TM2 helix	293..317	CDD:349858	8/23 (35%)
		TM3 helix	325..351	CDD:349858	5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..515		4/23 (17%)
		LGIC_TM	<604..636	CDD:365787	16/30 (53%)
		TM4 helix	612..633	CDD:349850	12/20 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900