Protein Alignment Grd and gabrp

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_005173350.2
• Gene: gabrp / 566633
• ZFINID: ZDB-GENE-081028-62
• Length: 464
• Species: Danio rerio
• Alignment Length: 574
• Identity: 155/574 - (27%)
• Similarity: 246/574 - (42%)
• Gaps: 168/574 - (29%)

  Fly   105 NHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRL 169
            |.:.:...:..|::||:..:||:|...|..|.:.:.:.|:..|||::|.|:...:.||.|.|.||
Zfish    50 NDSQLQPTIQKLMKGYNRYLRPNFNEGPVEIGMSLDIASIDAISEINMDYTATIFLRQRWRDSRL 114

  Fly   170 AFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCP 234
            .|.| .::|:|...:::.:|.|||:..:.|:|:||.:|..|:.:||:.||.|||:.|:|....|.
Zfish   115 IFPG-NESLSLDGRLVSLLWIPDTFIPDSKRSFLHDVTVENRLIRIFSNGTVLYALRITATIACN 178

  Fly   235 MNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYK 299
            |:|..:|||.|:|.|:..|:||...||::.|.:....|...:.::|:|:. |:....::|..||:
Zfish   179 MDLTKYPMDRQECTLQLESWGYNLEDVVFYWTRGNDSVKGLDTLRLAQYS-VESYYTSVTKAVYE 242

  Fly   300 AAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGL 364
                                                                          |||
Zfish   243 --------------------------------------------------------------TGL 245

  Fly   365 SGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGIT 429
                         |..|:::|.|:|::..|:::.|.|..|||||||||||:::.:...|..:|:|
Zfish   246 -------------YPKLILHFALRRNVLFFILETYVPSTLLVVLSWVSFWISQSSVPARTCIGVT 297

  Fly   430 TVLTMTFLGLEARTDLPKVS-YPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIE-- 491
            ||||||.|.:.|||.||..: :..|:|.::.:.|.|||..:|::|..|:.|.    :...||:
Zfish   298 TVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFTFIFGALLEYACAHFCTM----QHQTIIDVQ 358

  Fly   492 -ELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLW 555
             ||..|..||         .|:|.           ...||.|
Zfish   359 RELLKEFEES---------NGTTH-----------LVSSMSP----------------------- 380

  Fly   556 SMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRR 620
                         ||....||.:.|..|||       .|.....|..|...:...::
Zfish   381 -------------RKMKTEDSTKQEKPEQT-------VTCEENEAVEQTKEKGCGLT-------- 417

  Fly   621 MSYYRREEMEARRKGKRTPQYNSVS---KIDRASRIVFPLLFILINVFYWYGYL 671
                     ..::..:|.....||.   .|||.:||:||:.|:|||:|||..||
Zfish   418 ---------TVKQMSRRAASMMSVENPHNIDRHARILFPMAFLLINIFYWLYYL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	152/565 (27%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	59/167 (35%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
gabrp	XP_005173350.2	None