Protein Alignment Grd and gabrb4

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_005173931.1
• Gene: gabrb4 / 566514
• ZFINID: ZDB-GENE-070424-211
• Length: 512
• Species: Danio rerio
• Alignment Length: 612
• Identity: 174/612 - (28%)
• Similarity: 275/612 - (44%)
• Gaps: 157/612 - (25%)

  Fly    92 SSSLPSSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSM 156
            |||..|:.::.:..      .:|.||:|||..:||||||||..:.:.|.:.|:..||||:|.|::
Zfish    27 SSSTGSTGISVAKT------TVDKLLKGYDIRLRPDFGGPPVIVGMSINIASIDSISEVNMDYTI 85

  Fly   157 DCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRV 221
            ..||:|||.|||||:......|.|...:..::|.|||||.|.|:|:||.:|..|:.:|::.:|.|
Zfish    86 TMYFQQSWRDKRLAYAEMALNLTLDNRVADQLWLPDTYFLNDKKSFLHGVTVKNRMIRLHPDGTV 150

  Fly   222 LYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLV 286
            ||..|:|..|.|.|:|..:|:|.|.|.|:..|:||||.|:::.|......|...:.::|.||.:|
Zfish   151 LYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIVFFWQGGDNAVTGVDKLELPQFSIV 215

  Fly   287 DCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTG 351
            :                                                     |:|      ..
Zfish   216 E-----------------------------------------------------LRL------VS 221

  Fly   352 RDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLN 416
            |:....:||                 |..|.::|.::|::|.|::|.|.|..|:.:|||||||:|
Zfish   222 REVRFTTGS-----------------YPRLSLSFRIKRNIGYFILQTYMPSILITILSWVSFWIN 269

  Fly   417 REATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKY 481
            .:|:|.||:||:|||||||.:....|..|||:.|..|:|.::...|.|:|..:|::|.|: |..:
Zfish   270 YDASAARVALGVTTVLTMTTINTHLRETLPKIPYVKAIDVYLMGCFVFVFLALLEYAFVN-YVFF 333

  Fly   482 GSG--ECYFIIEELDSESGE---------SETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPT 535
            |.|  :...|.|.|:..:.|         .|.:.:::.|:.:|
Zfish   334 GRGPQQQKKINERLNKANNERPRYEEKRLREQDSISAPFQSNT---------------------- 376

  Fly   536 RLGMLTSRNRRPRN------RRHGL--WSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEA 592
                |.|..:| ||      |:.|:  :...||...:......|  :|......|.:..:.:.:
Zfish   377 ----LRSYTQR-RNLYLEEQRKVGVDAYGNILLTTLEMNNEVMP--SDVGSSVSDSRNSVMSFD- 433

  Fly   593 PTTSAAAAAAQAAAQAARISPPTGGRRRMSYYR--REEMEA-------RRKGK---RTPQYNSVS 645
                         :...:...|.|.|...|::.  |..|.:       ||..|   :.|....||
Zfish   434 -------------SSGVQFRKPMGSRDGFSHHSLDRSAMRSRANCRLRRRSSKLKLKIPNLTDVS 485

  Fly   646 KIDRASRIVFPLLFILINVFYWYGYLS 672
            .||:.|||:||:.|...|:.||..|::
Zfish   486 TIDKWSRIIFPITFGFFNLIYWLYYVN 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	169/589 (29%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	62/167 (37%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
gabrb4	XP_005173931.1	LIC	13..510	CDD:273305	173/608 (28%)