Protein Alignment Grd and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 87/456 - (19%)
• Similarity: 154/456 - (33%)
• Gaps: 125/456 - (27%)

  Fly   102 QSNNHANISELLDNLLRGYDNSIRPDFGGPPAT-IEVDIMVRSMGPISEVDMTYSMDCYFRQSWV 165
            |:|..|  ..|.|:||..|:..|||........ :::.:.:..:..::..|...:.:.:....|.
  Fly    40 QANPDA--KRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQ 102

  Fly   166 DKRLAFE-----GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSS 225
            |.:..::     |..:....|    ..||.||...||..... :.:||..|.: ::..|:|:::.
  Fly   103 DHKFKWDPSEYGGVTELYVPS----EHIWLPDIVLYNNADGE-YVVTTMTKAI-LHYTGKVVWTP 161

  Fly   226 RLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDV----IYRWNKERPPVAIAEDMK----LSQ 282
            ....|:.|.:::..||.|.|.|.:||||:.|....:    |.:.|.:...|.|..|::    ..:
  Fly   162 PAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVE 226

  Fly   283 FDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGA 347
            :|::..||..........|.|.|.  .|.|....|.|.........|.
  Fly   227 WDILGVPAERHEKYYPCCAEPYPD--IFFNITLRRKTLFYTVNLIIPC----------------- 272

  Fly   348 FGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVS 412
                          .|:|            |..::| |:|....|..:     ..|:.::||...
  Fly   273 --------------VGIS------------YLSVLV-FYLPADSGEKI-----ALCISILLSQTM 305

  Fly   413 FWLNREATADRVSL----------------GITTVLTMTFLGLEARTDLPKVSYPTALDFFV--- 458
            |:|.........||                |::.|:|:..|.:..|........|....||:
  Fly   306 FFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPSTHKMRPWIRSFFIKRL 370

  Fly   459 -------------------FLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEP 504
                               .:::|..|:.          ||:|..    :::|:...||.|..:.
  Fly   371 PKLLLMRVPKDLLRDLAANKINYGLKFSK----------TKFGQA----LMDEMQMNSGGSSPDS 421

  Fly   505 L 505
            |
  Fly   422 L 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	84/447 (19%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	36/181 (20%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	52/228 (23%)
		LIC	47..544	CDD:455710	84/447 (19%)
		Cys-loop	169..183	CDD:349832	5/13 (38%)