Protein Alignment Grd and nAChRalpha1

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 116/598 - (19%)
• Similarity: 214/598 - (35%)
• Gaps: 154/598 - (25%)

  Fly   112 LLDNLLRGYDNSIRP-DFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE--- 172
            |.|:||..|:..||| .......|:::.:.:..:..::..:...:.:.:..|.|.|.:|.:.
  Fly    28 LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDD 92

  Fly   173 -GAQDTLALSVSMLARIWKPDTYFYNGKQ-SYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPM 235
             |..|||.:...   .||.||...||... :|..||.|  |.: ::..|:|::......|:.|.:
  Fly    93 YGGVDTLHVPSE---HIWLPDIVLYNNADGNYEVTIMT--KAI-LHHTGKVVWKPPAIYKSFCEI 151

  Fly   236 NLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300
            ::..||.|.|.|.:||||:.|....|..|..|:   .|.::::::. .||.|.......||:
  Fly   152 DVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQ---TADSDNIEVG-IDLQDYYISVEWDIM--- 209

  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLS 365
                                :|      ||.:|:.....
  Fly   210 --------------------RV------PAVRNEKFYSC-------------------------- 222

  Fly   366 GTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITT 430
                  ...|  |..::.|..|:|....:.:.:..||..:..||.:.|:|..: :.:::||.|:.
  Fly   223 ------CEEP--YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSD-SGEKISLCISI 278

  Fly   431 VLTMTFLGLEARTDLPKVSYPTAL--DFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEEL 493
            :|::|...|.....:|..|....|  .:.:|.......:.::..||::...:
  Fly   279 LLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFR------------- 330

  Fly   494 DSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMP---------PP---------PTRLGML 540
                     .|:|.......:....:::|..:| |..|         ||         |..:...
  Fly   331 ---------SPVTHRMAPWVQRLFIQILPKLLC-IERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385

  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRR--------RKPPRADS-----DEDEDDEQTQLRANEA 592
            .:.:.:..:..:|:.::.....||....        .:||...|     .:|:....:.|..:.:
  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450

  Fly   593 PTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKG--------KRTPQYNSVSKIDR 649
            |....|||||.||..:.....|         |.| |||...:|        |...::.||.:..:
  Fly   451 PGCCPAAAAAAAADLSPTFEKP---------YAR-EMEKTIEGSRFIAQHVKNKDKFESVEEDWK 505

  Fly   650 ASRIVFPLLFILI 662
            ...:|...:|:.|
  Fly   506 YVAMVLDRMFLWI 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	52/219 (24%)
		LIC	111..670	CDD:273305	116/598 (19%)
		Neur_chan_memb	398..667	CDD:280999	56/306 (18%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	60/284 (21%)
		LIC	27..530	CDD:273305	116/598 (19%)
		Neur_chan_memb	247..530	CDD:280999	56/306 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030