Protein Alignment Grd and HisCl1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 646
• Identity: 139/646 - (21%)
• Similarity: 229/646 - (35%)
• Gaps: 240/646 - (37%)

  Fly    40 KLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSN 104
            ||:...||:.|.||.:|...||        .....:.|..:.....|:.:...|||
  Fly     7 KLVEFRCLIALAIYLHALEQSI--------QHCHCVHGYRNNTESAELVSHYESSL--------- 54

  Fly   105 NHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRL 169
               ::.::|....:.||.:..|...|.|..:...:.|.|:..|:|..|||..|.:..|||.|.||
  Fly    55 ---SLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRL 116

  Fly   170 AF--EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAG 232
            ..  ..::....|.|..|..||:||.:|.|.|:...|.::.||.::.:|.:..:||.|:||:...
  Fly   117 RLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLS 181

  Fly   233 CPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDL-----VDCPAGN 292
            |.|....:|.|.|.|.:...|..:|..|:::.||. ..|:.:..:::|.|.|:     .||
  Fly   182 CAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNM-TDPLVVNTEIELPQLDISNNYTTDC---- 241

  Fly   293 LTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGG 357
                                                                             
  Fly   242 ----------------------------------------------------------------- 241

  Fly   358 SGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATAD 422
                     ||...|.:   ::.|.:.|:|:|.:|..|...|.|..|:||:||:|||:..||...
  Fly   242 ---------TIEYSTGN---FTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPA 294

  Fly   423 RVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECY 487
            ||:||:|::||:.....:::..||.|||..|:|.::.....|:|.::::||||
  Fly   295 RVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVV------------ 347

  Fly   488 FIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRH 552
                               ::|.|...:|
  Fly   348 -------------------NNFMGPVATK------------------------------------ 357

  Fly   553 GLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGG 617
               :||  |..|          ::..|.||.::.|:
  Fly   358 ---AMK--GYSD----------ENISDLDDLKSALQ----------------------------- 378

  Fly   618 RRRMSYYRREEMEARRKGKRTPQYNSVSK-------IDRASRIVFPLLFILINVFYWYGYL 671
                 ::|...:|        |||::...       ||:.||..||..|.::|:.||..:|
  Fly   379 -----HHRESIIE--------PQYDTFCHGHATAIYIDKFSRFFFPFSFFILNIVYWTTFL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	123/572 (22%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	51/174 (29%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	57/265 (22%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	33/116 (28%)
		TM1 helix	265..288	CDD:349851	11/22 (50%)
		TM2 helix	292..316	CDD:349851	7/23 (30%)
		TM3 helix	324..350	CDD:349851	8/56 (14%)