Protein Alignment Grd and nAChRalpha4

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 78/374 - (20%)
• Similarity: 139/374 - (37%)
• Gaps: 103/374 - (27%)

  Fly   112 LLDNLLRGYDNSIRPDFGGPPATIEVDIMVR-SMGPISEVDM---TYSMDCYFRQSWVDKRLAFE 172
            |.|:||..|:..:||...   .|..:.:.:: .:..:.:|::   ..:.:.:..|||.|.:|.:|
  Fly    15 LYDDLLSNYNKLVRPVVN---TTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76

  Fly   173 GAQDTLALSVSML----ARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGC 233
            ..:..   .|.||    ..||:||...||....... :|...| ..||..|.|.:......|:.|
  Fly    77 PKEYG---GVHMLHVPSDHIWRPDIVLYNNADGNFE-VTLATK-ATIYSEGLVEWKPPAIYKSSC 136

  Fly   234 PMNLADFPMDIQKCPLKFGSFGYTTSDVIYR-WNKERPPVAIAEDMKLSQF------DLVDCPAG 291
            .:::..||.|.|.|.|||||:.|....|..| .::::....:|..:.||:|      |:::.
  Fly   137 EIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV--- 198

  Fly   292 NLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATG 356
                                                 ||.:|:            .|.|..|
  Fly   199 -------------------------------------PAVRNE------------KFYTCCD--- 211

  Fly   357 GSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATA 421
                               ..|..:..|..::|....:.:.:..||..:..|:.::|:|..: :.
  Fly   212 -------------------EPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSD-SG 256

  Fly   422 DRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATIL 470
            ::|:|.|:.::::....|.....:|    ||:| ....|....|||.||
  Fly   257 EKVTLSISILISLHVFFLLVVEIIP----PTSL-VVPLLGKYLIFAMIL 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	50/228 (22%)
		LIC	111..670	CDD:273305	78/374 (21%)
		Neur_chan_memb	398..667	CDD:280999	19/73 (26%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	78/374 (21%)
		Neur_chan_LBD	12..227	CDD:280998	59/293 (20%)
		Neur_chan_memb	234..505	CDD:280999	19/73 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030