Protein Alignment Grd and pHCl-1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 838
• Identity: 174/838 - (20%)
• Similarity: 273/838 - (32%)
• Gaps: 283/838 - (33%)

  Fly     4 MPATRDAS-----GSGDASTDLIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGP 63
            ||||..|:     |:..|:|...|.:.|..|....|....| ...|..|||||....|
  Fly   249 MPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISF-YAASSVLLMLCYLTTA------- 305

  Fly    64 GSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLL--RGYD----- 121
               ..:.:..|..|..|.|.:..:          .| ::.:..::..|:||.||  :.||
  Fly   306 ---STAAATQSETGALDKHPIHGI----------DW-SKFDESSSDKEILDLLLEKKRYDKRLLP 356

  Fly   122 --------------------NSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVD 166
                                |:.||...| ..|:.|::::.|:....|..:.|.::....|.|.|
  Fly   357 PVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWND 420

  Fly   167 KRLAF--EGAQDTLALSVSMLARIWKPDTYF-YNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLT 228
            .||.:  :...|.|. ::.....||.||||| .:|  .:...|...:..:||::||.:.|:.|..
  Fly   421 PRLQYGNKSHYDFLN-ALHHHDSIWTPDTYFIMHG--DFKDPIIPMHFALRIFRNGTITYAMRRH 482

  Fly   229 IKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNL 293
            :...|..:|..||.|..||.....|..|..:.:.|.|.
  Fly   483 LILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWK--------------------------- 520

  Fly   294 TDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGS 358
                             |::|..| .|..:||......|||              .|..|.....
  Fly   521 -----------------NDEDTLR-KSPSLTTLNAYLIKNQ--------------TTACDQNSWR 553

  Fly   359 GSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADR 423
            |:                 ||.|.|.....|....:...|:.|..:||..|:::|||...|...|
  Fly   554 GN-----------------YSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPAR 601

  Fly   424 VSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTK-------- 480
            |.:|:||:|.........|:.||.||..||::.:..:...||:|::|:|..|:|..:
  Fly   602 VMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVV 666

  Fly   481 YGSGECYFIIEELD---SESGESETEPLTSDFRGSTESKIYEVIPLS------MCAISMPPPPTR 536
            |..|| ..:.:.|.   |..|.....||.|.......|.:....|:|      ..:::.|..| |
  Fly   667 YRPGE-NPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTP-R 729

  Fly   537 L---------GM------------------------------LTSRNRRPRNR--RH-------- 552
            :         ||                              .||.:..|..|  .|
  Fly   730 ITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGS 794

  Fly   553 --GLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQA----------- 604
              |:.|.|:        :.|....:...:|.:..|:||.:.|.:|.|.....:|
  Fly   795 TSGVTSTKV--------KFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPI 851

  Fly   605 -----------------AAQAARISPP-------------TGGRRRMSYYRREEMEA-------- 631
                             ..:|:|.:.|             |.|.:|.:.....|:.|
  Fly   852 QDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSN 916

  Fly   632 ------------------RRKGKRTPQYNSVSK-IDRASRIVFPLLFILINVFYWYGY 670
                              :.:.|..|....|:| ||..:||.||..:.:..:|::..|
  Fly   917 SPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHY 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	148/724 (20%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	38/170 (22%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	95/402 (24%)
		LGIC_TM	<948..975	CDD:476813	9/27 (33%)
		TM4 helix	950..971	CDD:349850	7/20 (35%)