DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grd and pHCl-1

DIOPT Version :9

Sequence 1:	NP_524131.1	Gene:	Grd / 39984	FlyBaseID:	FBgn0001134	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	174/838 - (20%)
Similarity:	273/838 - (32%)	Gaps:	283/838 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MPATRDAS-----GSGDASTDLIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGP 63
            ||||..|:     |:..|:|...|.:.|..|....|....| ...|..|||||....|
  Fly   249 MPATMSAAIIANVGATAAATSAAAFQYLGQHYKHYSQSISF-YAASSVLLMLCYLTTA------- 305

  Fly    64 GSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLL--RGYD----- 121
               ..:.:..|..|..|.|.:..:          .| ::.:..::..|:||.||  :.||
  Fly   306 ---STAAATQSETGALDKHPIHGI----------DW-SKFDESSSDKEILDLLLEKKRYDKRLLP 356

  Fly   122 --------------------NSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVD 166
                                |:.||...| ..|:.|::::.|:....|..:.|.::....|.|.|
  Fly   357 PVNDEDFCCGLQSPDMATNQNARRPHNRG-TLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWND 420

  Fly   167 KRLAF--EGAQDTLALSVSMLARIWKPDTYF-YNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLT 228
            .||.:  :...|.|. ::.....||.||||| .:|  .:...|...:..:||::||.:.|:.|..
  Fly   421 PRLQYGNKSHYDFLN-ALHHHDSIWTPDTYFIMHG--DFKDPIIPMHFALRIFRNGTITYAMRRH 482

  Fly   229 IKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNL 293
            :...|..:|..||.|..||.....|..|..:.:.|.|.
  Fly   483 LILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWK--------------------------- 520

  Fly   294 TDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGS 358
                             |::|..| .|..:||......|||              .|..|.....
  Fly   521 -----------------NDEDTLR-KSPSLTTLNAYLIKNQ--------------TTACDQNSWR 553

  Fly   359 GSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADR 423
            |:                 ||.|.|.....|....:...|:.|..:||..|:::|||...|...|
  Fly   554 GN-----------------YSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWNAVPAR 601

  Fly   424 VSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTK-------- 480
            |.:|:||:|.........|:.||.||..||::.:..:...||:|::|:|..|:|..:
  Fly   602 VMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKRPLHNVV 666

  Fly   481 YGSGECYFIIEELD---SESGESETEPLTSDFRGSTESKIYEVIPLS------MCAISMPPPPTR 536
            |..|| ..:.:.|.   |..|.....||.|.......|.:....|:|      ..:::.|..| |
  Fly   667 YRPGE-NPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSVATPGTP-R 729

  Fly   537 L---------GM------------------------------LTSRNRRPRNR--RH-------- 552
            :         ||                              .||.:..|..|  .|
  Fly   730 ITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHIYEEPGGS 794

  Fly   553 --GLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQA----------- 604
              |:.|.|:        :.|....:...:|.:..|:||.:.|.:|.|.....:|
  Fly   795 TSGVTSTKV--------KFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPI 851

  Fly   605 -----------------AAQAARISPP-------------TGGRRRMSYYRREEMEA-------- 631
                             ..:|:|.:.|             |.|.:|.:.....|:.|
  Fly   852 QDMEMTERQLSLPLKPPRRKASRSNSPASVYSDAFENVEATPGEKRQNAGAPNEIVACTTCGGSN 916

  Fly   632 ------------------RRKGKRTPQYNSVSK-IDRASRIVFPLLFILINVFYWYGY 670
                              :.:.|..|....|:| ||..:||.||..:.:..:|::..|
  Fly   917 SPCTHSANNGCATETCFVQVRKKEPPHPIRVAKTIDVIARITFPTAYAIFLIFFFVHY 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	54/245 (22%)
		LIC	111..670	CDD:273305	148/724 (20%)
		Neur_chan_memb	398..667	CDD:280999	82/404 (20%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	65/307 (21%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	32/104 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010