DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grd and lgc-36

DIOPT Version :9

Sequence 1:	NP_524131.1	Gene:	Grd / 39984	FlyBaseID:	FBgn0001134	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001023766.1	Gene:	lgc-36 / 3565335	WormBaseID:	WBGene00008551	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	668	Identity:	195/668 - (29%)
Similarity:	303/668 - (45%)	Gaps:	170/668 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSI------GPGSGPFSVSADSIKGRGDTHRLGEM 87
            |:..:..:.:....||..:|.:|  .|...::|      .|||  |.:       :...|...|.
Worm     3 HRISKFTVSLIIFFISTIILSVC--GNELKFTIENVKFRSPGS--FRI-------KRTVHPKREK 56

  Fly    88 GTSLSSSLPSSWLTQSNNHANISELLDNLLRGYDNSIRPDF-GGPPATIEVDIMVRSMGPISEVD 151
            |.:                .|::.||:|:|:.||...||.| .|.|..:.:|:.:|:|||:|::.
Worm    57 GVA----------------QNVTHLLNNVLKNYDQHFRPGFNSGKPTKVYIDLFIRTMGPVSDLF 105

  Fly   152 MTYSMDCYFRQSWVDKRLAFEGAQ---DTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFV 213
            .|||.:|||||.|.|.||.|..:.   ..|:||::||.:||||||||:||..||:|.|||.|:.|
Worm   106 NTYSFNCYFRQKWTDDRLHFNNSGIGFRQLSLSMAMLDKIWKPDTYFWNGAGSYVHGITTSNRLV 170

  Fly   214 RIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAED- 277
            |:..:|.:|||||:|:||.|.|:::.:|:|.|.|.|..||:.|::.:|.|:|.      .:.:|
Worm   171 RLEPDGTILYSSRITVKAKCQMDMSRYPLDKQACRLVIGSYAYSSDEVQYKWR------IMGDDN 229

  Fly   278 -MKLSQFDLVDCPAGNLTDI-VYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTG 340
             :|:....:.|.|..:|:.. |||.|                                      .
Worm   230 GVKIDYESIADLPQFSLSGFKVYKPA--------------------------------------N 256

  Fly   341 LKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLL 405
            :..||                               |||.|.|.|:..||.|.||:..|.||.|:
Worm   257 ITRDK-------------------------------EYSALEVRFYFDRHFGYFLMNFYVPCALV 290

  Fly   406 VVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATIL 470
            |:|.||:|:..|||||:|:.:|||.|||:..:.:::::|.|||..||||:.|:::.:......::
Worm   291 VLLCWVAFFTKREATAERIGIGITNVLTIVLISMDSKSDSPKVDSPTALEVFIWICYLTHLICMV 355

  Fly   471 QFAVVHYYTKYGSGECYF----------IIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSM 525
            :|.||||:|||.:|:...          ||:::...:....|||   .||....:     :|:|
Worm   356 EFTVVHYHTKYNTGDPEIQEVERERLRQIIKQIPKNTNNRATEP---TFRRRNAA-----LPVS- 411

  Fly   526 CAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRAN 590
              |:.|.|               |:.....|:           |:|.::     |..|..||...
Worm   412 --IARPLP---------------NKTKRFMSV-----------RQPKKS-----EQTESIQLMRK 443

  Fly   591 EAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVF 655
            .:...|......:::.....|.....|.|  .||...:...:.......| ||.|:||:.|.||.
Worm   444 ISNMESTTHNEVESSLNLESIRQENVGWR--LYYWMIDHNIKTDPFGVAQ-NSTSRIDKISVIVA 505

  Fly   656 PLLFILINVFYWYGYLSR 673
            ||:|||....|:..|::|
Worm   506 PLIFILTIALYYDFYVNR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	85/222 (38%)
		LIC	111..670	CDD:273305	178/575 (31%)
		Neur_chan_memb	398..667	CDD:280999	79/278 (28%)
lgc-36	NP_001023766.1	LIC	48..520	CDD:273305	182/607 (30%)
		Neur_chan_LBD	63..272	CDD:280998	93/283 (33%)
		Neur_chan_memb	284..511	CDD:280999	77/271 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I2091
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4372
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.730