Protein Alignment Grd and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 125/636 - (19%)
• Similarity: 219/636 - (34%)
• Gaps: 187/636 - (29%)

  Fly    91 LSSSLPSSW-----------LTQSNNHANISELLDNLLRGYDNSIRPDFG-GPPATIEVDIMVRS 143
            :.|.||:|.           :.:|....:...||::||..|:...||... ..|..::..:.::.
  Fly     1 MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQ 65

  Fly   144 MGPISEVDMTYSMDCYFRQSWVDKRL-----AFEGAQDTLALSVSMLARIWKPDTYFYN----GK 199
            :..:.|.:...:.:.:....|.|..|     .:.|.:| |.::.:   ::||||...||    |.
  Fly    66 IIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKD-LRITPN---KLWKPDVLMYNSADEGF 126

  Fly   200 QSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYR 264
            ....||    |..|:  .||..||......|:.|.:::..||.|.|.|.:||||:.|..:.:
  Fly   127 DGTYHT----NIVVK--HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQL--- 182

  Fly   265 WNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGP 329
                        |:.|:..|     .|:|:|.:                     |:......|.|
  Fly   183 ------------DLVLNSED-----GGDLSDFI---------------------TNGEWYLLAMP 209

  Fly   330 AAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNF 394
            ..||..|...                                  .|..|..:.....::|....:
  Fly   210 GKKNTIVYAC----------------------------------CPEPYVDITFTIQIRRRTLYY 240

  Fly   395 LIQVYGPCCLLVVLSWVSF----------------------WLNREA-----TADRVSL-GITTV 431
            ...:..||.|:..::.:.|                      :||..|     |:|.|.| |:|.:
  Fly   241 FFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTIL 305

  Fly   432 LTMT-FLGLEARTDLPKVS--YPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEEL 493
            |::| ||.|.|.| ||:||  .|....:|..:.|....:.:|...|::|:.:
  Fly   306 LSLTVFLNLVAET-LPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHR------------- 356

  Fly   494 DSESGESETEPLTSDFRGSTESKIYEVIP-LSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSM 557
                        |:|        |:|:.| :....:...|...|:|    |..|...|:..|.|.
  Fly   357 ------------TAD--------IHEMPPWIKSVFLQWLPWILRMG----RPGRKITRKTILLSN 397

  Fly   558 KLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMS 622
            ::..|....|..|...|:..:.:||.:..:..::....|:|:.......:....:  .|...:..
  Fly   398 RMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTA--IGCNHKDL 460

  Fly   623 YYRREEME--ARRKGKRTPQYNSVSK-------IDRASRIVFPLLFILINV 664
            :...:|::  ..|..|...:...:..       :||...|||.|..|:..|
  Fly   461 HLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATV 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	120/605 (20%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	41/176 (23%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	121/626 (19%)
		LGIC_ECD_nAChR	55..236	CDD:349798	48/265 (18%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)