Protein Alignment Grd and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 470
• Identity: 96/470 - (20%)
• Similarity: 169/470 - (35%)
• Gaps: 114/470 - (24%)

  Fly    87 MGTSLS--SSLPSSWLTQSNNHANISELLDNLLRG----YDNSIRPDFGGPPATIEVDIMVRSMG 145
            ||..|.  :|:|.:..|....:||: :.||.|..|    ||:.::|.|.|.|..:.::::|..:
  Fly    24 MGMLLMGLTSVPGATATADPKNANV-KALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEMVVTYI- 86

  Fly   146 PISEVDMTYSMDCYFRQSWVDKRLAFEGAQ-DTLALSVSMLARIWKPDTYFYNGKQSYLHTITTP 209
            .|.|::...:..|:....|.|:...::.:| |.:.......:.:|.|....:||.:..|...|.
  Fly    87 DIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQ- 150

  Fly   210 NKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAI 274
               |.:..:|...:.......|.|.:|:.::|.|.|.|.||.||:|.   .|:.      |....
  Fly   151 ---VTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGL---KVVL------PENGT 203

  Fly   275 AEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGT 339
            |....|...|||..|...:.|          .|..|.::|
  Fly   204 ARGESLDHDDLVQSPEWEIVD----------SRAHFVSQD------------------------- 233

  Fly   340 GLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCL 404
                                                 .|..:......||....:...:|.|...
  Fly   234 -------------------------------------YYGYMEYTLTAQRRSSMYTAVIYTPASC 261

  Fly   405 LVVLSWVSFWLNREATADRVSL-GITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIF-- 466
            :|:|:..:|||......:::.: |:..::...||...|:. ||.:|..|.| ..:|.|...::
  Fly   262 IVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQL-LPVLSNNTPL-VVIFYSTSLLYLS 324

  Fly   467 -ATILQFAVVHYYT------------KYGSGEC-YFIIEELDSESGESETEPLTS-DFRGSTESK 516
             :||::..|::..|            |...|.. .:::..:.|.:|||:.|.... |.....|:.
  Fly   325 VSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEAD 389

  Fly   517 IYEVIPLSMCAISMP 531
            ..|..||.:....:|
  Fly   390 EQESSPLGINHTEVP 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	88/444 (20%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	38/168 (23%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	91/455 (20%)