Protein Alignment Grd and glra1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_021336638.1
• Gene: glra1 / 30676
• ZFINID: ZDB-GENE-991117-1
• Length: 457
• Species: Danio rerio
• Alignment Length: 604
• Identity: 175/604 - (28%)
• Similarity: 249/604 - (41%)
• Gaps: 220/604 - (36%)

  Fly   110 SELLDNLL---RGYDNSIRPDF-------------GGPPATIEVDIMVRSMGPISEVDMTYSMDC 158
            ||.||.|:   .|||..|||:|             .|||..:..:|.:.|.|.|:|..|.|.::.
Zfish    35 SEFLDKLMGKVSGYDARIRPNFKDPQGSKSDGTHKKGPPVNVTCNIFINSFGSIAETTMDYRVNI 99

  Fly   159 YFRQSWVDKRLAF-EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVL 222
            :.||.|.|.|||: |...|:|.|..|||..|||||.:|.|.|.:..|.:||.||.:||.:||.||
Zfish   100 FLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVL 164

  Fly   223 YSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVD 287
            ||.|:|:...|||:|.:||||:|.|.::..|||||.:|:|:.|: |:..|.:|:.:.|.||.|.:
Zfish   165 YSIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWD-EKGAVQVADGLTLPQFILKE 228

  Fly   288 CPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGR 352
                                    .||                          |:.....:.||:
Zfish   229 ------------------------EKD--------------------------LRYCTKHYNTGK 243

  Fly   353 DATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNR 417
                                     ::.:...|||:|.||.:|||:|.|..|:|:|||||||:|.
Zfish   244 -------------------------FTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINM 283

  Fly   418 EATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYG 482
            :|...||.||||||||||.....:|..||||||..|:|.::.:...|:|:.:|::|.|::..:..
Zfish   284 DAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQH 348

  Fly   483 SGECYFIIEEL-----------DSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPP--P 534
                    :||           :.|:|:..                     .|..|..|.|.  .
Zfish   349 --------KELLRFQRRRRHLKEDEAGDGR---------------------FSFAAYGMGPACLQ 384

  Fly   535 TRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAA 599
            .:.||....|.                                            |.|||::
Zfish   385 AKDGMAIKGNN--------------------------------------------NNAPTST--- 402

  Fly   600 AAAQAAAQAARISPPTGGRRRMSYYRREEMEARRK-----GKRTPQYNSVSKIDRASRIVFPLLF 659
                        :||           .:.:|..||     .||         ||..||:.|||:|
Zfish   403 ------------NPP-----------EKTVEEMRKLFISRAKR---------IDTVSRVAFPLVF 435

  Fly   660 ILINVFYWYGY-LSRSSRI 677
            ::.|:|||..| :.||..|
Zfish   436 LIFNIFYWITYKIIRSEDI 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	170/593 (29%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	70/168 (42%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
glra1	XP_021336638.1	LIC	7..446	CDD:273305	171/594 (29%)