Protein Alignment Grd and Gabra6

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_068613.2
• Gene: Gabra6 / 29708
• RGDID: 61861
• Length: 453
• Species: Rattus norvegicus
• Alignment Length: 594
• Identity: 188/594 - (31%)
• Similarity: 269/594 - (45%)
• Gaps: 193/594 - (32%)

  Fly   108 NISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE 172
            |:|.:|||||.||||.:||.|||....::.||.|.|.||:|:|:|.|:||.:|||:|.|:||.|:
  Rat    31 NVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFK 95

  Fly   173 GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNL 237
            |..:.|:|:..|:::||.|||:|.|||:|..|.:|||||..|:.|||.:||:.||||.|.|||.|
  Rat    96 GPAEILSLNNLMVSKIWTPDTFFQNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRL 160

  Fly   238 ADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAI---AEDMKLSQFDLVDCPAGNLTDIVYK 299
            .:||||...|||||||:.|..|::||.| |:.|..::   .|...|.|:||:
  Rat   161 VNFPMDGHACPLKFGSYAYPKSEIIYTW-KKGPLYSVEVPEESSSLLQYDLI------------- 211

  Fly   300 AAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGL 364
                                        |....::.::                      |.||
  Rat   212 ----------------------------GQTVSSETIK----------------------SNTG- 225

  Fly   365 SGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGIT 429
                        ||.::.|.|||||.||.|:||:|.||.:.|:||.||||:|:|:...|...|||
  Rat   226 ------------EYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGIT 278

  Fly   430 TVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELD 494
            ||||||.|.:.||..||||||.||:|:|:.:.|.|:|:.:::||.|:|:|            .|.
  Rat   279 TVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT------------NLQ 331

  Fly   495 SESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKL 559
            |:..|.:.:...
  Rat   332 SQKAERQAQTAA----------------------------------------------------- 343

  Fly   560 LGLFDWRRRRKPPRADSDEDE---------DDEQTQLRANEAPTTSAAAAAAQAAAQAAR----- 610
                      |||.|.|...|         .|.:..|:...:..|.....:::|:...:|
  Rat   344 ----------KPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILP 398

  Fly   611 ---ISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLS 672
               ::||.                     ..|.....||||:.|||:||:.|...|:.||..|||
  Rat   399 STPVTPPL---------------------LLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLS 442

  Fly   673 RSSRILANT 681
            :.:..:::|
  Rat   443 KDTMEVSST 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	182/578 (31%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	78/170 (46%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
Gabra6	NP_068613.2	LIC	34..440	CDD:455710	182/578 (31%)
		LGIC_ECD	42..239	CDD:475126	98/273 (36%)