Protein Alignment Grd and GLRA1

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001139512.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 457
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 176/592 - (29%)
• Similarity: 257/592 - (43%)
• Gaps: 175/592 - (29%)

  Fly    90 SLSSSLPSSWLTQSNNHANISELLDNLL---RGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVD 151
            ||::|..:.....:....:.|:.||.|:   .|||..|||:|.|||..:..:|.:.|.|.|:|..
Human    19 SLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETT 83

  Fly   152 MTYSMDCYFRQSWVDKRLAF-EGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRI 215
            |.|.::.:.||.|.|.|||: |...|:|.|..|||..|||||.:|.|.|.::.|.|||.||.:||
Human    84 MDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRI 148

  Fly   216 YQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKL 280
            .:||.||||.|:|:...|||:|.:||||:|.|.::..|||||.:|:|:.| :|:..|.:|:.:.|
Human   149 SRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QEQGAVQVADGLTL 212

  Fly   281 SQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDK 345
            .||.|.:                        .||                          |:...
Human   213 PQFILKE------------------------EKD--------------------------LRYCT 227

  Fly   346 GAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSW 410
            ..:.||:                         ::.:...|||:|.||.:|||:|.|..|:|:|||
Human   228 KHYNTGK-------------------------FTCIEARFHLERQMGYYLIQMYIPSLLIVILSW 267

  Fly   411 VSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVV 475
            :|||:|.:|...||.||||||||||.....:|..||||||..|:|.::.:...|:|:.:|::|.|
Human   268 ISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAV 332

  Fly   476 HYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGML 540
            ::.::                   ...|.|.  ||
Human   333 NFVSR-------------------QHKELLR--FR------------------------------ 346

  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRAN-------EAPTTSAA 598
                   |.|||  ....:|.||                ::||..:.|.|       .|...:..
Human   347 -------RKRRH--HKSPMLNLF----------------QEDEAGEGRFNFSAYGMGPACLQAKD 386

  Fly   599 AAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILIN 663
            ..:.:.|..:...:||....:     ..|||       |........|||:.|||.||:.|::.|
Human   387 GISVKGANNSNTTNPPPAPSK-----SPEEM-------RKLFIQRAKKIDKISRIGFPMAFLIFN 439

  Fly   664 VFYWYGY 670
            :|||..|
Human   440 MFYWIIY 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	86/219 (39%)
		LIC	111..670	CDD:273305	171/569 (30%)
		Neur_chan_memb	398..667	CDD:280999	72/275 (26%)
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	175/590 (30%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	230..235		2/29 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810