Protein Alignment Grd and GABRR2

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 163/558 - (29%)
• Similarity: 246/558 - (44%)
• Gaps: 160/558 - (28%)

  Fly   116 LLR--GYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQD-T 177
            |||  .:|.|:||.||||...:.||:.|.|:..||||||.::|..|.|..|.|:||||..|.: :
Human    58 LLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKS 122

  Fly   178 LALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPM 242
            :.....::.:||.||.:|.:.|:|:.|..||.|..:|::.:|.||||.|:|:.|.|.|:.:.||:
Human   123 MTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPL 187

  Fly   243 DIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQR 307
            |.|.|.|:..|:.||..|::..|......:...|.:.||||            ::.|
Human   188 DSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQF------------LIQK-------- 232

  Fly   308 RPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLET 372
              |:.      ||::                        ||          .|:||.
Human   233 --FHT------TSRL------------------------AF----------YSSTGW-------- 247

  Fly   373 NHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFL 437
                 |:.|.:||.|:||:..||:|.|.|..|:|:|||||||::|.|...|||||||||||||.:
Human   248 -----YNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTI 307

  Fly   438 GLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESET 502
            .......:|:|||..|:|.::::||.|:|.::|::|.|:|.|         .::|
Human   308 ITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLT---------TVQE---------- 353

  Fly   503 EPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRR 567
                     ..|.|:.|..| .||           |||.|:            :|.|.|.:....
Human   354 ---------RKERKLREKFP-CMC-----------GMLHSK------------TMMLDGSYSESE 385

  Fly   568 RRK---PPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEM 629
            ...   .||:....:|:      |.::.......:..|.||.:...:...||.|
Human   386 ANSLAGYPRSHILTEEE------RQDKIVVHLGLSGEANAARKKGLLKGQTGFR----------- 433

  Fly   630 EARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYW 667
                      .:.:...||:.||::||..:|..|:.||
Human   434 ----------IFQNTHAIDKYSRLIFPASYIFFNLIYW 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	73/212 (34%)
		LIC	111..670	CDD:273305	163/558 (29%)
		Neur_chan_memb	398..667	CDD:280999	73/271 (27%)
GABRR2	NP_002034.3	Neur_chan_LBD	51..464	CDD:332142	163/558 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6761
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810