Protein Alignment Grd and GABRG3

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_011519732.1
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 473
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 194/639 - (30%)
• Similarity: 276/639 - (43%)
• Gaps: 187/639 - (29%)

  Fly    47 LLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSW-LTQSNNHANIS 110
            ||:||::           ||   :.|.|.|...|.:.        .||....| |...:...:::
Human     6 LLLLCLF-----------SG---LHARSRKVEEDEYE--------DSSSNQKWVLAPKSQDTDVT 48

  Fly   111 ELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQ 175
            .:|:.|||.||..:|||.|..|..|:|||.|.|:||:|.::|.|.:|.:|.|:|.|.||.|....
Human    49 LILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTM 113

  Fly   176 DTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADF 240
            ..|.|:.:|:..||.|||.|.|.|.:..|.|||||:.:||:.:|::||:.||||.|.|.:.|.:|
Human   114 KILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNF 178

  Fly   241 PMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRP 305
            |||...|||.|.|:||...::||||.|.....|..:..:|.|||.:..
Human   179 PMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGL----------------- 226

  Fly   306 QRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITL 370
                       |.|::::||.||
Human   227 -----------RNTTEIVTTSAG------------------------------------------ 238

  Fly   371 ETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMT 435
                  :|.::.:.|.|.|.||.|.||.|.||.|.|||||||||:.::||..|.:||||||||||
Human   239 ------DYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMT 297

  Fly   436 FLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGES 500
            .|...||..||:|||.||:|.||.:.|.|:||.::::|.::||:               |....:
Human   298 TLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS---------------SCRKPT 347

  Fly   501 ETEPLTSDFRGSTESKIYEVIPL----------SMCAISMPPPPTRLGMLTSRNRRPRNRRHGLW 555
            .|:..||.....:...|.|.|.|          :...:.|.||||  .|:|..|.
Human   348 TTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDMRPPPT--AMITLNNS---------- 400

  Fly   556 SMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRR 620
                   ..|:           |.||                           ..:.....|:..
Human   401 -------VYWQ-----------EFED---------------------------TCVYECLDGKDC 420

  Fly   621 MSY---YRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            .|:   |...:..:.|||:   .:..:.::|..||:.||..|:|.|:.||.|||
Human   421 QSFFCCYEECKSGSWRKGR---IHIDILELDSYSRVFFPTSFLLFNLVYWVGYL 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	83/215 (39%)
		LIC	111..670	CDD:273305	177/571 (31%)
		Neur_chan_memb	398..667	CDD:280999	80/281 (28%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	90/280 (32%)
		LIC	50..470	CDD:273305	177/570 (31%)
		Neur_chan_memb	260..467	CDD:280999	80/281 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.010