Protein Alignment Grd and GABRG1

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_775807.2
• Gene: GABRG1 / 2565
• HGNCID: 4086
• Length: 465
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 185/576 - (32%)
• Similarity: 263/576 - (45%)
• Gaps: 166/576 - (28%)

  Fly    98 SWLTQSNNH-ANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFR 161
            :|:.....| .:|:::|::||:||||.:|||.|..|..||.|:.|.|:||:..::|.|::|..|.
Human    52 TWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFA 116

  Fly   162 QSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSR 226
            |:|.|.||.|......|.|:.:|:.:||.|||:|.|.::|..|.|||||:.:||:.:|||||:.|
Human   117 QTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLR 181

  Fly   227 LTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAG 291
            |||.|.|.:.|.:||||...|||:|.|:||..:::.|:|.|....||..:..:|.||..|
Human   182 LTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFV----- 241

  Fly   292 NLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATG 356
                                                            ||:
Human   242 ------------------------------------------------GLR-------------- 244

  Fly   357 GSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATA 421
               ::|.::.||:      .:|.::.:.|.|.|.||.|.||.|.||.|.|||||||||:|::|..
Human   245 ---NSTEITHTIS------GDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP 300

  Fly   422 DRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGEC 486
            .|.|||||||||||.|...||..||||||.||:|.||.:.|.|:||.::::..:||:|....|:.
Human   301 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKT 365

  Fly   487 YFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRR 551
            .....:|.:::  |.|..|   ..|||      :||::  .||:|
Human   366 ATKDRKLKNKA--SMTPGL---HPGST------LIPMN--NISVP-------------------- 397

  Fly   552 HGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQ-LRANEAPTTSAAAAAAQAAAQAARISPPT 615
                                       .|||...| |...:       .|:.....:..|    |
Human   398 ---------------------------QEDDYGYQCLEGKD-------CASFFCCFEDCR----T 424

  Fly   616 GGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            |..|....:.|                 ::|||..|||.||..|.|.|:.||.|||
Human   425 GSWREGRIHIR-----------------IAKIDSYSRIFFPTAFALFNLVYWVGYL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	80/215 (37%)
		LIC	111..670	CDD:273305	179/559 (32%)
		Neur_chan_memb	398..667	CDD:280999	83/269 (31%)
GABRG1	NP_775807.2	LIC	66..462	CDD:273305	179/559 (32%)
		LGIC_ECD_GABAAR_G	88..269	CDD:349801	76/256 (30%)
		Cys-loop	188..202	CDD:349801	6/13 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.010