Protein Alignment Grd and GABRB1

DIOPT Version :10

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 179/574 - (31%)
• Similarity: 264/574 - (45%)
• Gaps: 134/574 - (23%)

  Fly   102 QSNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVD 166
            :.:|.:.:.|.:|.||:|||..:||||||||..:.:.|.|.|:..:|||:|.|::..||:|||.|
Human    30 EPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKD 94

  Fly   167 KRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKA 231
            |||::.|....|.|...:..::|.|||||.|.|:|::|.:|..|:.:|::.:|.|||..|:|..|
Human    95 KRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTA 159

  Fly   232 GCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDI 296
            .|.|:|..:|:|.|.|.|:..|:||||.|:.:.||.....|.....::|.||.:||
Human   160 ACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVD--------- 215

  Fly   297 VYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGST 361
             ||..:.:.:                                         |.||
Human   216 -YKMVSKKVE-----------------------------------------FTTG---------- 228

  Fly   362 TGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSL 426
                           .|..|.::|.|:|::|.|::|.|.|..|:.:|||||||:|.:|:|.||:|
Human   229 ---------------AYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVAL 278

  Fly   427 GITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIE 491
            |||||||||.:....|..|||:.|..|:|.::...|.|:|..:|::|.|:|.. :|.|.......
Human   279 GITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIF-FGKGPQKKGAS 342

  Fly   492 ELDSESGES---ETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHG 553
            :.|..:.|.   |...:..|..|:        |.||...|                   ||...|
Human   343 KQDQSANEKNKLEMNKVQVDAHGN--------ILLSTLEI-------------------RNETSG 380

  Fly   554 LWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAA-RISPPTGG 617
              |..|..:.|       |:| :....|....|.|   .|.:|     .:|..:|. |...|:.|
Human   381 --SEVLTSVSD-------PKA-TMYSYDSASIQYR---KPLSS-----REAYGRALDRHGVPSKG 427

  Fly   618 RRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYL 671
            |.|    ||    |.:...:.|....|:.||:.||:.||:.|.|.||.||..|:
Human   428 RIR----RR----ASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYV 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	LIC	111..670	CDD:455710	177/562 (31%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	64/167 (38%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	178/571 (31%)