Protein Alignment Grd and GABRA6

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 199/609 - (32%)
• Similarity: 282/609 - (46%)
• Gaps: 188/609 - (30%)

  Fly    91 LSSSLPSSWL--------------TQSNNHA-NISELLDNLLRGYDNSIRPDFGGPPATIEVDIM 140
            ::||||  ||              .:.|.:: |:|.:|||||.||||.:||.|||....::.||.
Human     1 MASSLP--WLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIY 63

  Fly   141 VRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHT 205
            |.|.||:|:|:|.|:||.:|||:|.|:||.|.|..:.|:|:..|:::||.|||:|.|||:|..|.
Human    64 VTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHN 128

  Fly   206 ITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNK--- 267
            :|||||..||.|||.:||:.||||.|.|||.|.:||||...|||||||:.|..|::||.|.|
Human   129 MTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPL 193

  Fly   268 ---ERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGP 329
               |.|    .|...|.|:||:                                         |.
Human   194 YSVEVP----EESSSLLQYDLI-----------------------------------------GQ 213

  Fly   330 AAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNF 394
            ...::.::                      |.||             ||.::.|.|||||.||.|
Human   214 TVSSETIK----------------------SNTG-------------EYVIMTVYFHLQRKMGYF 243

  Fly   395 LIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVF 459
            :||:|.||.:.|:||.||||:|:|:...|...|||||||||.|.:.||..||||||.||:|:|:.
Human   244 MIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIA 308

  Fly   460 LSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETE---PLTSDFRGSTESKIYEVI 521
            :.|.|:|:.:::||.|:|:|            .|.::..:.:.:   |.|.....:||....|::
Human   309 VCFAFVFSALIEFAAVNYFT------------NLQTQKAKRKAQFAAPPTVTISKATEPLEAEIV 361

  Fly   522 PLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQ 586
                                   ..|.::.|....:..|.|         |...|.|
Human   362 -----------------------LHPDSKYHLKKRITSLSL---------PIVSSSE-------- 386

  Fly   587 LRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRAS 651
              ||:..|.:       ...|:..::||                     ..:|.:...||||:.|
Human   387 --ANKVLTRA-------PILQSTPVTPP---------------------PLSPAFGGTSKIDQYS 421

  Fly   652 RIVFPLLFILINVFYWYGYLSRSS 675
            ||:||:.|...|:.||..|||:.:
Human   422 RILFPVAFAGFNLVYWVVYLSKDT 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	95/221 (43%)
		LIC	111..670	CDD:273305	187/567 (33%)
		Neur_chan_memb	398..667	CDD:280999	74/271 (27%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	194/598 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	1	0.950	-	0	Normalized mean entropy	S4372
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820