DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grd and GABRA5

DIOPT Version :9

Sequence 1:NP_524131.1 Gene:Grd / 39984 FlyBaseID:FBgn0001134 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_000801.1 Gene:GABRA5 / 2558 HGNCID:4079 Length:462 Species:Homo sapiens


Alignment Length:588 Identity:190/588 - (32%)
Similarity:275/588 - (46%) Gaps:174/588 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 SSLP-SSWLTQSNNHANI-SELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYS 155
            |.:| ||...::|::..| :.:||.||.||||.:||..|.....:..||.|.|.||:|:.:|.|:
Human    31 SQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYT 95

  Fly   156 MDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGR 220
            :|.:|||||.|:||.|:|....|.|:..:.::||.|||:|:|||:|..|.:|||||.:|:..:|.
Human    96 IDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGT 160

  Fly   221 VLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRW-NKERPPVAIAED-MKLSQF 283
            :||:.||||.|.|||.|.|||||...|||||||:.|..|:|:|.| |.....|.:||| .:|:|:
Human   161 LLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQY 225

  Fly   284 DLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAF 348
            .|:                                                              
Human   226 HLM-------------------------------------------------------------- 228

  Fly   349 GTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSF 413
                      |.|.   ||..:.|: ..||:::..:|||:|.:|.|:||.|.||.:.|:||.|||
Human   229 ----------GQTV---GTENISTS-TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSF 279

  Fly   414 WLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYY 478
            |||||:...|...|:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.:::||.|:|:
Human   280 WLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 344

  Fly   479 TKYG---SGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGML 540
            ||.|   .|:     :.|::...:.:.|.:.:                                 
Human   345 TKRGWAWDGK-----KALEAAKIKKKREVILN--------------------------------- 371

  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAA 605
                             |....|...:...||....      |||.  |..:.|||.:...::  
Human   372 -----------------KSTNAFTTGKMSHPPNIPK------EQTP--AGTSNTTSVSVKPSE-- 409

  Fly   606 AQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGY 670
                                    |...:.|:|  |||:||||:.||||||:||...|:.||..|
Human   410 ------------------------EKTSESKKT--YNSISKIDKMSRIVFPVLFGTFNLVYWATY 448

  Fly   671 LSR 673
            |:|
Human   449 LNR 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GrdNP_524131.1 Neur_chan_LBD 110..326 CDD:280998 87/217 (40%)
LIC 111..670 CDD:273305 181/563 (32%)
Neur_chan_memb 398..667 CDD:280999 77/271 (28%)
GABRA5NP_000801.1 LGIC_ECD_GABAAR_A5 58..256 CDD:349839 93/273 (34%)
LGIC_TM_GABAAR_alpha 259..445 CDD:349854 80/276 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..412 11/68 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 199 1.000 Domainoid score I3055
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 373 1.000 Inparanoid score I2115
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1057372at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X127
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.970

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