DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grd and GABRA4

DIOPT Version :9

Sequence 1:	NP_524131.1	Gene:	Grd / 39984	FlyBaseID:	FBgn0001134	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_000800.2	Gene:	GABRA4 / 2557	HGNCID:	4078	Length:	554	Species:	Homo sapiens

Alignment Length:	606	Identity:	196/606 - (32%)
Similarity:	286/606 - (47%)	Gaps:	144/606 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 NISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE 172
            |.:.:||:||.||||.:||.||||...::.||.|.|.||:|:|:|.|:||.:|||:|:||||.::
Human    47 NFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111

  Fly   173 GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNL 237
            |..:.|.|:..|:.::|.|||:|.|||:|..|.:|.|||..||.:||.:||:.||||.|.|||.|
Human   112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRL 176

  Fly   238 ADFPMDIQKCPLKFGSFGYTTSDVIYRWNK--ERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300
            .|||||...|||||||:.|..|::||.|.|  |:......|...|.|:||:
Human   177 VDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI-------------- 227

  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLS 365
                                       |....::.::                      |.||
Human   228 ---------------------------GQTVSSETIK----------------------SITG-- 241

  Fly   366 GTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITT 430
                       ||.::.|.|||:|.||.|:||.|.||.:.|:||.||||:|:|:...|...||||
Human   242 -----------EYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITT 295

  Fly   431 VLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDS 495
            |||||.|.:.||..||||||.||:|:|:.:.|.|:|:.:::||.|:|:|            .:..
Human   296 VLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT------------NIQM 348

  Fly   496 ESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGL------ 554
            |..:.:|            ||..:.:|.:  .:.....|......|:.|...|.|.:.|
Human   349 EKAKRKT------------SKPPQEVPAA--PVQREKHPEAPLQNTNANLNMRKRTNALVHSESD 399

  Fly   555 -WSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGR 618
             .:...:|    ....|......:..:...::.|.::..|.:.|.||...:||:|...:.||..|
Human   400 VGNRTEVG----NHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIR 460

  Fly   619 -----RRMSY---YRREEMEARRKGKRT---------------------PQYNSVSKIDRASRIV 654
                 |:.|.   ..|....:|.:..:|                     |..:..||||:.:||:
Human   461 TGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARIL 525

  Fly   655 FPLLFILINVFYWYGYLSRSS 675
            ||:.|...|:.||..|||:.:
Human   526 FPVTFGAFNMVYWVVYLSKDT 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	91/217 (42%)
		LIC	111..670	CDD:273305	192/596 (32%)
		Neur_chan_memb	398..667	CDD:280999	83/304 (27%)
GABRA4	NP_000800.2	Neur_chan_LBD	13..541	CDD:332142	193/599 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..381		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..435		3/41 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..471		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..515		1/19 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960