Protein Alignment Grd and GABRA3

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_000799.1
• Gene: GABRA3 / 2556
• HGNCID: 4077
• Length: 492
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 199/628 - (31%)
• Similarity: 293/628 - (46%)
• Gaps: 168/628 - (26%)

  Fly    55 NAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLLRG 119
            |..|.:.|.|........|.:|     ..:|.:....:..:|..   .::|....:.:||.||.|
Human    21 NILPGTTGQGESRRQEPGDFVK-----QDIGGLSPKHAPDIPDD---STDNITIFTRILDRLLDG 77

  Fly   120 YDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSM 184
            |||.:||..|.....::.||.|.|.||:|:.||.|::|.:|||:|.|:||.|:|....|.|:..:
Human    78 YDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLL 142

  Fly   185 LARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPL 249
            .::||.|||:|:|||:|..|.:|||||.:|:..||.:||:.||||.|.|||:|.|||||:..|||
Human   143 ASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPL 207

  Fly   250 KFGSFGYTTSDVIYRW----NKERPPVAIAED-MKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRP 309
            ||||:.|||::|:|.|    ||.   |.:|:| .:|:|:||:.
Human   208 KFGSYAYTTAEVVYSWTLGKNKS---VEVAQDGSRLNQYDLLG---------------------- 247

  Fly   310 FNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNH 374
                                     ||.||.:.         |.:||
Human   248 -------------------------HVVGTEII---------RSSTG------------------ 260

  Fly   375 PSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGL 439
              ||.::..:|||:|.:|.|:||.|.||.:.|:||.||||||||:...|...|:|||||||.|.:
Human   261 --EYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSI 323

  Fly   440 EARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEP 504
            .||..||||:|.||:|:|:.:.:.|:|:.:::||.|:|:||             .|.:.|.:..|
Human   324 SARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK-------------RSWAWEGKKVP 375

  Fly   505 LTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRR 569
            ...:.:..|                 |..|.:....|               ..::|
Human   376 EALEMKKKT-----------------PAAPAKKTSTT---------------FNIVG-------- 400

  Fly   570 KPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRK 634
                           |....|.|..|. .:..::.||.:|..:|......:.:|.:....|
Human   401 ---------------TTYPINLAKDTE-FSTISKGAAPSASSTPTIIASPKATYVQDSPTE---- 445

  Fly   635 GKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSRI 677
               |..||||||:|:.|||:||:||.:.|:.||..|::|.|.|
Human   446 ---TKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAI 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	90/220 (41%)
		LIC	111..670	CDD:273305	186/563 (33%)
		Neur_chan_memb	398..667	CDD:280999	77/268 (29%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..54		5/30 (17%)
		LIC	69..478	CDD:273305	186/563 (33%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	99/277 (36%)
		Cys-loop	191..205	CDD:349837	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20218
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.970