Protein Alignment Grd and GABRA2

DIOPT Version :9

• Sequence 1: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 198/593 - (33%)
• Similarity: 291/593 - (49%)
• Gaps: 132/593 - (22%)

  Fly   104 NNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKR 168
            ||....:.:||.||.||||.:||..|.....:..:|.|.|.||:|:.||.|::|.:|||.|.|:|
Human    37 NNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101

  Fly   169 LAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGC 233
            |.|:|..:.|.|:..|.::||.|||:|:|||:|..|.:|.|||.:||..:|.:||:.|||::|.|
Human   102 LKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAEC 166

  Fly   234 PMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWN-KERPPVAIAED-MKLSQFDLVDCPAGNLTDI 296
            ||:|.|||||...|||||||:.||||:|.|.|. .....|.:|.| .:|:|:||:....|..|
Human   167 PMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKET-- 229

  Fly   297 VYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGST 361
                                                        :|                 |:
Human   230 --------------------------------------------IK-----------------SS 233

  Fly   362 TGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSL 426
            ||             ||:::..:|||:|.:|.|:||.|.||.:.|:||.||||||||:...|...
Human   234 TG-------------EYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVF 285

  Fly   427 GITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYG---SGECYF 488
            |:|||||||.|.:.||..||||:|.||:|:|:.:.:.|:|:.:::||.|:|:||.|   .|:
Human   286 GVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGK--- 347

  Fly   489 IIEELDSESGESETEPLTSDFRGSTESKIY--EVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRR 551
              ..::.:|...:.|.:|..: .|.::.:.  ::|.....|.|.|
Human   348 --SVVNDKSPSIKAEGITLTY-NSVKAILQGAKLIWSKYIAFSWP-------------------- 389

  Fly   552 HGLWSMKLLGLFD-W------RRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAA 609
             .|:..|.|...: |      ::..|..:| |...:::......||.||..|.....:..:..|.
Human   390 -SLFQEKTLEYLEKWMDCLTFKQSSKKEKA-SVMIQNNAYAVAVANYAPNLSKDPVLSTISKSAT 452

  Fly   610 RISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRS 674
            ...|           .::......:.|:|  :||||||||.||||||:||...|:.||..||:|.
Human   453 TPEP-----------NKKPENKPAEAKKT--FNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNRE 504

  Fly   675 SRILANTP 682
            . :|..:|
Human   505 P-VLGVSP 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	89/217 (41%)
		LIC	111..670	CDD:273305	191/572 (33%)
		Neur_chan_memb	398..667	CDD:280999	86/280 (31%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	193/579 (33%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	97/277 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.160